2UW9

STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-chloro-phenyl)-4-(4-(1H-pyrazol-4-yl)-phenyl)-piperidine

Summary for 2UW9

• Entry DOI: 10.2210/pdb2uw9/pdb
• Related: 1GNG 1GZK 1GZN 1GZO 1H8F 1I09 1J1B 1J1C 1MRV 1MRY 1O6K 1O6L 1O9U 1P6S 1PYX 1Q3D 1Q3W 1Q41 1Q4L 1Q5K 1R0E 1UV5 2JDO 2JDR
• Descriptor: RAC-BETA SERINE/THREONINE-PROTEIN KINASE, GLYCOGEN SYNTHASE KINASE-3 BETA, 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE, ... (4 entities in total)
• Functional Keywords: transferase/inhibitor, transferase-inhibitor complex, wnt signaling pathway, serine/threonine-protein kinase, kinase, transferase, atp-binding, phosphorylation, nucleotide-binding, alternative splicing
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm: P49841
• Total number of polymer chains: 2
• Total formula weight: 41321.45

Authors

Davies, T.G.,Saxty, G.,Woodhead, S.J.,Berdini, V.,Verdonk, M.L.,Wyatt, P.G.,Boyle, R.G.,Barford, D.,Downham, R.,Garrett, M.D.,Carr, R.A. (deposition date: 2007-03-19, release date: 2007-05-08, Last modification date: 2011-07-13)

• Primary citation: Saxty, G.,Woodhead, S.J.,Berdini, V.,Davies, T.G.,Verdonk, M.L.,Wyatt, P.G.,Boyle, R.G.,Barford, D.,Downham, R.,Garrett, M.D.,Carr, R.A.; Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery.; J.Med.Chem., 50:2293-, 2007; PubMed: 17451234; DOI: 10.1021/JM070091B

Experimental method

X-RAY DIFFRACTION (2.1 Å)