2XWB

Crystal Structure of Complement C3b in complex with Factors B and D

Summary for 2XWB

• Entry DOI: 10.2210/pdb2xwb/pdb
• Related: 1BIO 1C3D 1DFP 1DIC 1DLE 1DST 1DSU 1FDP 1GHQ 1HFD 1Q0P 1RRK 1RS0 1RTK 1W2S 2A73 2A74 2HR0 2WII 2WIN 2WY7 2WY8 2XQW 2XW9 2XWA 2XWJ
• Descriptor: COMPLEMENT C3B BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR B, ... (10 entities in total)
• Functional Keywords: immune system, pro-convertase, hydrolase, serine protease, conformational changes, alternative pathway
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P01024 P01024 P00751 P00746
• Total number of polymer chains: 8
• Total formula weight: 566820.38

Authors

Forneris, F.,Ricklin, D.,Wu, J.,Tzekou, A.,Wallace, R.S.,Lambris, J.D.,Gros, P. (deposition date: 2010-11-01, release date: 2011-01-12, Last modification date: 2023-12-20)

• Primary citation: Forneris, F.,Ricklin, D.,Wu, J.,Tzekou, A.,Wallace, R.S.,Lambris, J.D.,Gros, P.; Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.; Science, 330:1816-, 2010; PubMed: 21205667; DOI: 10.1126/SCIENCE.1195821

Experimental method

X-RAY DIFFRACTION (3.49 Å)