2WIN

C3 convertase (C3bBb) stabilized by SCIN

Summary for 2WIN

Related1DLE 1Q0P 2A73 1RRK 2WII 1RTK 2A74 2ICF 2QFF 2I6Q
DescriptorCOMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR B, ... (10 entities in total)
Functional Keywordsserine protease, immune response, innate immunity, zymogen, secreted, protease, glycation, alternative pathway, disease mutation, hydrolase, convertase, complement, polymorphism, immune evasion, immune system
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationSecreted P01024 P01024 Q6GFB4
Total number of polymer chains16
Total molecular weight985531.47
Authors
Wu, J.,Janssen, B.J.,Gros, P. (deposition date: 2009-05-13, release date: 2009-06-09, Last modification date: 2018-01-17)
Primary citation
Rooijakkers, S.H.,Wu, J.,Ruyken, M.,van Domselaar, R.,Planken, K.L.,Tzekou, A.,Ricklin, D.,Lambris, J.D.,Janssen, B.J.,van Strijp, J.A.,Gros, P.
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.
Nat. Immunol., 10:721-727, 2009
PubMed: 19503103 (PDB entries with the same primary citation)
DOI: 10.1038/ni.1756
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.261142.0%2.7%2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report