Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2WIN

C3 convertase (C3bBb) stabilized by SCIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004866	molecular_function	endopeptidase inhibitor activity
B	0004866	molecular_function	endopeptidase inhibitor activity
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
C	0004866	molecular_function	endopeptidase inhibitor activity
D	0004866	molecular_function	endopeptidase inhibitor activity
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
E	0004866	molecular_function	endopeptidase inhibitor activity
F	0004866	molecular_function	endopeptidase inhibitor activity
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
G	0004866	molecular_function	endopeptidase inhibitor activity
H	0004866	molecular_function	endopeptidase inhibitor activity
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
I	0004252	molecular_function	serine-type endopeptidase activity
I	0006508	biological_process	proteolysis
J	0004252	molecular_function	serine-type endopeptidase activity
J	0006508	biological_process	proteolysis
K	0004252	molecular_function	serine-type endopeptidase activity
K	0006508	biological_process	proteolysis
L	0004252	molecular_function	serine-type endopeptidase activity
L	0006508	biological_process	proteolysis
M	0005576	cellular_component	extracellular region
N	0005576	cellular_component	extracellular region
P	0005576	cellular_component	extracellular region
Q	0005576	cellular_component	extracellular region

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
I	LEU497-CYS502

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. NTcrGDSGGPLI

Chain	Residue	Details
I	ASN668-ILE679

site_id	PS00477
Number of Residues	9
Details	ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEQnM

Chain	Residue	Details
B	PRO985-MET993

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Site: {"description":"(Microbial infection) Cleavage; by S.pyogenes SpeB","evidences":[{"source":"PubMed","id":"18160402","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	28
Details	Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16263699","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17051150","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17684013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2579379","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	64
Details	Peptide: {"description":"Complement C3f fragment","featureId":"PRO_0000005916","evidences":[{"source":"PubMed","id":"8376604","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	76
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	100
Details	Region: {"description":"Interaction with CFP/properdin","evidences":[{"source":"PubMed","id":"28264884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31507604","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	12
Details	Site: {"description":"Cleavage; by factor I","evidences":[{"source":"PubMed","id":"28671664","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Site: {"description":"Coordinates Mg(2+) for interaction with Complement factor B Bb fragment (CFB)","evidences":[{"source":"PubMed","id":"28264884","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31507604","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"14760718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17051150","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	8
Details	Cross-link: {"description":"Isoglutamyl cysteine thioester (Cys-Gln)","evidences":[{"source":"PubMed","id":"1577777","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6175959","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	286
Details	Domain: {"description":"NTR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00295","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	796
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	1120
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	12
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"10637221","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15016353","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Q0P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17310251","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6546754","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"2006911","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17310251","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19503103","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19574954","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6546754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WIN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	68
Details	Region: {"description":"Essential for activity"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
B	GLN991
B	CYS988

site_id	CSA10
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
J	GLY675
J	SER674
J	ASP551
J	HIS501

site_id	CSA11
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
K	GLY675
K	SER674
K	ASP551
K	HIS501

site_id	CSA12
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
L	GLY675
L	SER674
L	ASP551
L	HIS501

site_id	CSA13
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
I	SER674
I	ASP551
I	GLY672
I	HIS501

site_id	CSA14
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
J	SER674
J	ASP551
J	GLY672
J	HIS501

site_id	CSA15
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
K	SER674
K	ASP551
K	GLY672
K	HIS501

site_id	CSA16
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
L	SER674
L	ASP551
L	GLY672
L	HIS501

site_id	CSA17
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
I	ASP551
I	HIS501

site_id	CSA18
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
J	ASP551
J	HIS501

site_id	CSA19
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
K	ASP551
K	HIS501

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
D	GLN991
D	CYS988

site_id	CSA20
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
L	ASP551
L	HIS501

site_id	CSA21
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
I	SER674
I	GLY672

site_id	CSA22
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
J	SER674
J	GLY672

site_id	CSA23
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
K	SER674
K	GLY672

site_id	CSA24
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
L	SER674
L	GLY672

site_id	CSA25
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
I	GLY675
I	SER674

site_id	CSA26
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
J	GLY675
J	SER674

site_id	CSA27
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
K	GLY675
K	SER674

site_id	CSA28
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
L	GLY675
L	SER674

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
F	GLN991
F	CYS988

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
H	GLN991
H	CYS988

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
I	SER674
I	ASP551
I	HIS501

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
J	SER674
J	ASP551
J	HIS501

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
K	SER674
K	ASP551
K	HIS501

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
L	SER674
L	ASP551
L	HIS501

site_id	CSA9
Number of Residues	4
Details	Annotated By Reference To The Literature 1a0j

Chain	Residue	Details
I	GLY675
I	SER674
I	ASP551
I	HIS501

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)