2WIN
C3 convertase (C3bBb) stabilized by SCIN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004866 | molecular_function | endopeptidase inhibitor activity |
| B | 0004866 | molecular_function | endopeptidase inhibitor activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| C | 0004866 | molecular_function | endopeptidase inhibitor activity |
| D | 0004866 | molecular_function | endopeptidase inhibitor activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005615 | cellular_component | extracellular space |
| E | 0004866 | molecular_function | endopeptidase inhibitor activity |
| F | 0004866 | molecular_function | endopeptidase inhibitor activity |
| F | 0005576 | cellular_component | extracellular region |
| F | 0005615 | cellular_component | extracellular space |
| G | 0004866 | molecular_function | endopeptidase inhibitor activity |
| H | 0004866 | molecular_function | endopeptidase inhibitor activity |
| H | 0005576 | cellular_component | extracellular region |
| H | 0005615 | cellular_component | extracellular space |
| I | 0004252 | molecular_function | serine-type endopeptidase activity |
| I | 0005576 | cellular_component | extracellular region |
| I | 0006508 | biological_process | proteolysis |
| I | 0006956 | biological_process | complement activation |
| J | 0004252 | molecular_function | serine-type endopeptidase activity |
| J | 0005576 | cellular_component | extracellular region |
| J | 0006508 | biological_process | proteolysis |
| J | 0006956 | biological_process | complement activation |
| K | 0004252 | molecular_function | serine-type endopeptidase activity |
| K | 0005576 | cellular_component | extracellular region |
| K | 0006508 | biological_process | proteolysis |
| K | 0006956 | biological_process | complement activation |
| L | 0004252 | molecular_function | serine-type endopeptidase activity |
| L | 0005576 | cellular_component | extracellular region |
| L | 0006508 | biological_process | proteolysis |
| L | 0006956 | biological_process | complement activation |
| M | 0005576 | cellular_component | extracellular region |
| N | 0005576 | cellular_component | extracellular region |
| P | 0005576 | cellular_component | extracellular region |
| Q | 0005576 | cellular_component | extracellular region |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| I | LEU497-CYS502 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. NTcrGDSGGPLI |
| Chain | Residue | Details |
| I | ASN668-ILE679 |
| site_id | PS00477 |
| Number of Residues | 9 |
| Details | ALPHA_2_MACROGLOBULIN Alpha-2-macroglobulin family thiolester region signature. PsGCGEQnM |
| Chain | Residue | Details |
| B | PRO985-MET993 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| I | HIS501 | |
| L | HIS501 | |
| L | ASP551 | |
| L | SER674 | |
| I | ASP551 | |
| I | SER674 | |
| J | HIS501 | |
| J | ASP551 | |
| J | SER674 | |
| K | HIS501 | |
| K | ASP551 | |
| K | SER674 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6546754 |
| Chain | Residue | Details |
| I | ASN260 | |
| E | SER48 | |
| E | SER275 | |
| E | SER281 | |
| G | SER16 | |
| G | SER48 | |
| G | SER275 | |
| G | SER281 | |
| J | ASN260 | |
| K | ASN260 | |
| L | ASN260 | |
| F | ARG1281 | |
| F | ARG1298 | |
| H | ARG1281 | |
| H | ARG1298 | |
| E | SER16 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:2006911 |
| Chain | Residue | Details |
| I | LYS266 | |
| J | LYS266 | |
| K | LYS266 | |
| L | LYS266 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17310251, ECO:0000269|PubMed:19574954, ECO:0000269|PubMed:6546754 |
| Chain | Residue | Details |
| I | ASN353 | |
| H | SER946 | |
| H | SER1299 | |
| H | SER1551 | |
| J | ASN353 | |
| K | ASN353 | |
| L | ASN353 | |
| D | SER1299 | |
| D | SER1551 | |
| F | SER946 | |
| F | SER1299 | |
| F | SER1551 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:14760718, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:17051150 |
| Chain | Residue | Details |
| B | ASN917 | |
| D | ASN917 | |
| F | ASN917 | |
| H | ASN917 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 |
| Chain | Residue | Details |
| B | ASN1595 | |
| D | ASN1595 | |
| F | ASN1595 | |
| H | ASN1595 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | CROSSLNK: Isoglutamyl cysteine thioester (Cys-Gln) |
| Chain | Residue | Details |
| B | CYS988 | |
| B | GLN991 | |
| D | CYS988 | |
| D | GLN991 | |
| F | CYS988 | |
| F | GLN991 | |
| H | CYS988 | |
| H | GLN991 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | GLN991 | |
| B | CYS988 |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| J | GLY675 | |
| J | SER674 | |
| J | ASP551 | |
| J | HIS501 |
| site_id | CSA11 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| K | GLY675 | |
| K | SER674 | |
| K | ASP551 | |
| K | HIS501 |
| site_id | CSA12 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| L | GLY675 | |
| L | SER674 | |
| L | ASP551 | |
| L | HIS501 |
| site_id | CSA13 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| I | SER674 | |
| I | ASP551 | |
| I | GLY672 | |
| I | HIS501 |
| site_id | CSA14 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| J | SER674 | |
| J | ASP551 | |
| J | GLY672 | |
| J | HIS501 |
| site_id | CSA15 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| K | SER674 | |
| K | ASP551 | |
| K | GLY672 | |
| K | HIS501 |
| site_id | CSA16 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| L | SER674 | |
| L | ASP551 | |
| L | GLY672 | |
| L | HIS501 |
| site_id | CSA17 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| I | ASP551 | |
| I | HIS501 |
| site_id | CSA18 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| J | ASP551 | |
| J | HIS501 |
| site_id | CSA19 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| K | ASP551 | |
| K | HIS501 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| D | GLN991 | |
| D | CYS988 |
| site_id | CSA20 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| L | ASP551 | |
| L | HIS501 |
| site_id | CSA21 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| I | SER674 | |
| I | GLY672 |
| site_id | CSA22 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| J | SER674 | |
| J | GLY672 |
| site_id | CSA23 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| K | SER674 | |
| K | GLY672 |
| site_id | CSA24 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| L | SER674 | |
| L | GLY672 |
| site_id | CSA25 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| I | GLY675 | |
| I | SER674 |
| site_id | CSA26 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| J | GLY675 | |
| J | SER674 |
| site_id | CSA27 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| K | GLY675 | |
| K | SER674 |
| site_id | CSA28 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| L | GLY675 | |
| L | SER674 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| F | GLN991 | |
| F | CYS988 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| H | GLN991 | |
| H | CYS988 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| I | SER674 | |
| I | ASP551 | |
| I | HIS501 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| J | SER674 | |
| J | ASP551 | |
| J | HIS501 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| K | SER674 | |
| K | ASP551 | |
| K | HIS501 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| L | SER674 | |
| L | ASP551 | |
| L | HIS501 |
| site_id | CSA9 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| I | GLY675 | |
| I | SER674 | |
| I | ASP551 | |
| I | HIS501 |
