2WII

Complement C3b in complex with factor H domains 1-4

Summary for 2WII

Related1FHC 2JGW 2A74 2W81 2V8E 2W80 2A73 2JGX 1HFH 2G7I 2ICF 2RLP 2RLQ 1OJV
DescriptorCOMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR H, ... (8 entities in total)
Functional Keywordsimmune system, sushi, secreted, polymorphism, glycoprotein, complement system, complement pathway, immune response, innate immunity, disease mutation, inflammatory response, complement alternate pathway, cleavage on pair of basic residues, age-related macular degeneration, regulator of complement activation, alternative pathway, alternative splicing, phosphoprotein, disulfide bond, thioester bond
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P01024 P01024
Total number of polymer chains3
Total molecular weight209681.27
Authors
Wu, J.,Janssen, B.J.C.,Gros, P. (deposition date: 2009-05-12, release date: 2009-06-09, Last modification date: 2018-02-28)
Primary citation
Wu, J.,Wu, Y.Q.,Ricklin, D.,Janssen, B.J.,Lambris, J.D.,Gros, P.
Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.
Nat. Immunol., 10:728-733, 2009
PubMed: 19503104 (PDB entries with the same primary citation)
DOI: 10.1038/ni.1755
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24090.2%1.3%3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report