2A73

Human Complement Component C3

Summary for 2A73

• Entry DOI: 10.2210/pdb2a73/pdb
• Descriptor: Complement C3, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: intact thioester, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01024 P01024
• Total number of polymer chains: 2
• Total formula weight: 185685.22

Authors

Janssen, B.J.C.,Huizinga, E.G.,Raaijmakers, H.C.A.,Roos, A.,Daha, M.R.,Nilsson-Ekdahl, K.,Nilsson, B.,Gros, P. (deposition date: 2005-07-04, release date: 2005-09-27, Last modification date: 2023-08-23)

• Primary citation: Janssen, B.J.,Huizinga, E.G.,Raaijmakers, H.C.,Roos, A.,Daha, M.R.,Nilsson-Ekdahl, K.,Nilsson, B.,Gros, P.; Structures of complement component C3 provide insights into the function and evolution of immunity.; Nature, 437:505-511, 2005; PubMed: 16177781; DOI: 10.1038/nature04005

Experimental method

X-RAY DIFFRACTION (3.3 Å)