2WII

Complement C3b in complex with factor H domains 1-4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	COMPLEMENT C3 BETA CHAIN	polymer	645	71393.3	1	UniProt (P01024) Pfam (PF17790) Pfam (PF01835) Pfam (PF17791) Pfam (PF17789) Pfam (PF07703)	HOMO SAPIENS (HUMAN)	COMPLEMENT C3, C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 1
2	B (B)	COMPLEMENT C3B ALPHA' CHAIN	polymer	915	104073.2	1	UniProt (P01024) Pfam (PF07677) Pfam (PF01759) Pfam (PF00207) Pfam (PF21406) Pfam (PF07678) Pfam (PF21308)	HOMO SAPIENS (HUMAN)	COMPLEMENT C3, C3 AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 1
3	C (C)	COMPLEMENT FACTOR H	polymer	277	31224.9	1	UniProt (P08603) Pfam (PF00084)	HOMO SAPIENS (HUMAN)	H FACTOR 1
4	D (D)	beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-6)-[beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	1	In PDB GlyTouCan (G52684JK)
5	E (A)	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
6	F, G, H, I, J... (A, B, C)	GLYCEROL	non-polymer		92.1	17	Chemie (GOL)
7	V (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
8	X, Y, Z (A, B, C)	water	water		18.0	172	Chemie (HOH)

Sequence modifications

C: -4 - -1 (PDB: 2WII)
C: 247 - 272 (PDB: 2WII)
C: 0 - 246 (UniProt: P08603)

PDB	External Database	Details
Ile 44	Val 62	variant

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	206691.3
Branched	Number of molecules	1
	Total formula weight	1073.0
Non-Polymers*	Number of molecules	19
	Total formula weight	1826.9
All*	Total formula weight	209591.2

*Water molecules are not included.