2WII

Complement C3b in complex with factor H domains 1-4

Summary for 2WII

• Entry DOI: 10.2210/pdb2wii/pdb
• Related: 1FHC 1HFH 1OJV 2A73 2A74 2G7I 2ICF 2JGW 2JGX 2RLP 2RLQ 2V8E 2W80 2W81
• Descriptor: COMPLEMENT C3 BETA CHAIN, COMPLEMENT C3B ALPHA' CHAIN, COMPLEMENT FACTOR H, ... (8 entities in total)
• Functional Keywords: immune system, sushi, secreted, polymorphism, glycoprotein, complement system, complement pathway, immune response, innate immunity, disease mutation, inflammatory response, complement alternate pathway, cleavage on pair of basic residues, age-related macular degeneration, regulator of complement activation, alternative pathway, alternative splicing, phosphoprotein, disulfide bond, thioester bond
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P01024 P01024
• Total number of polymer chains: 3
• Total formula weight: 209591.19

Authors

Wu, J.,Janssen, B.J.C.,Gros, P. (deposition date: 2009-05-12, release date: 2009-06-09, Last modification date: 2023-12-13)

• Primary citation: Wu, J.,Wu, Y.Q.,Ricklin, D.,Janssen, B.J.,Lambris, J.D.,Gros, P.; Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.; Nat. Immunol., 10:728-733, 2009; PubMed: 19503104; DOI: 10.1038/ni.1755

Experimental method

X-RAY DIFFRACTION (2.7 Å)