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2V8E

Crystal structure of Human Complement Factor H, SCR domains 6-8 (H402 risk variant), in complex with ligand.

Summary for 2V8E
Entry DOI10.2210/pdb2v8e/pdb
Related1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2JGW 2JGX 2UWN
Related PRD IDPRD_900013
DescriptorCOMPLEMENT FACTOR H, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, CHLORIDE ION, ... (6 entities in total)
Functional Keywordsalternative splicing, sucrose octasulphate, age-related macular degeneration, sushi, secreted, factor h, complement, polymorphism, complement alternate pathway, immune system, disease mutation, glycosaminoglycan, glycoprotein, innate immunity, immune response
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted: P08603
Total number of polymer chains1
Total formula weight22721.53
Authors
Prosser, B.E.,Johnson, S.,Roversi, P.,Herbert, A.P.,Blaum, B.S.,Tyrrell, J.,Jowitt, T.A.,Clark, S.J.,Tarelli, E.,Uhrin, D.,Barlow, P.N.,Sim, R.B.,Day, A.J.,Lea, S.M. (deposition date: 2007-08-07, release date: 2007-10-02, Last modification date: 2023-12-13)
Primary citationProsser, B.E.,Johnson, S.,Roversi, P.,Herbert, A.P.,Blaum, B.S.,Tyrrell, J.,Jowitt, T.A.,Clark, S.J.,Tarelli, E.,Uhrin, D.,Barlow, P.N.,Sim, R.B.,Day, A.J.,Lea, S.M.
Structural Basis for Complement Factor H Linked Age-Related Macular Degeneration.
J.Exp.Med., 204:2277-, 2007
Cited by
PubMed: 17893204
DOI: 10.1084/JEM.20071069
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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