1BIO
HUMAN COMPLEMENT FACTOR D IN COMPLEX WITH ISATOIC ANHYDRIDE INHIBITOR
Summary for 1BIO
Entry DOI | 10.2210/pdb1bio/pdb |
Descriptor | COMPLEMENT FACTOR D, ISATOIC ANHYDRIDE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | serine protease, hydrolase, complement, factor d, catalytic triad, self-regulation |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00746 |
Total number of polymer chains | 1 |
Total formula weight | 24654.05 |
Authors | Jing, H.,Babu, Y.S.,Moore, D.,Kilpatrick, J.M.,Liu, X.-Y.,Volanakis, J.E.,Narayana, S.V.L. (deposition date: 1998-06-18, release date: 1999-06-22, Last modification date: 2023-08-02) |
Primary citation | Jing, H.,Babu, Y.S.,Moore, D.,Kilpatrick, J.M.,Liu, X.Y.,Volanakis, J.E.,Narayana, S.V. Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity. J.Mol.Biol., 282:1061-1081, 1998 Cited by PubMed: 9753554DOI: 10.1006/jmbi.1998.2089 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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