2XF0

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Summary for 2XF0

Related2WMT 2CGX 2BRO 2C3J 2BRB 2WMW 2X8D 2WMU 2WMR 2BRH 2CGV 2X8E 2C3K 1NVR 2WMQ 2CGW 1ZLT 2BRN 2WMX 2AYP 1ZYS 2CGU 1IA8 2BR1 2BRG 1NVS 1NVQ 2BRM 2WMS 2WMV 2C3L 2X8I 2XEZ 2XEY
DescriptorSERINE/THREONINE-PROTEIN KINASE CHK1, 3-PHENYL-6-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordstransferase, dna repair, cell cycle
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus O14757
Total number of polymer chains1
Total molecular weight33552.54
Authors
Primary citation
Matthews, T.P.,Mchardy, T.,Klair, S.,Boxall, K.,Fisher, M.,Cherry, M.,Allen, C.E.,Addison, G.J.,Ellard, J.,Aherne, G.W.,Westwood, I.M.,Montfort, R.V.,Garrett, M.D.,Reader, J.C.,Collins, I.
Design and Evaluation of 3,6-Di(Hetero)Aryl Imidazo[1,2-A]Pyrazines as Inhibitors of Checkpoint and Other Kinases.
Bioorg.Med.Chem.Lett., 20:4045-, 2010
PubMed: 20561787 (PDB entries with the same primary citation)
DOI: 10.1016/J.BMCL.2010.05.096
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.240190.4%0.4%8.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution