2XEZ

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Summary for 2XEZ

Related2BRB 2X8D 2WMR 2CGV 2BRN 2AYP 2WMX 2CGU 1NVS 2BRM 1NVQ 2WMT 2CGX 2BRO 2C3J 2WMW 2WMU 2BRH 2X8E 2C3K 1NVR 2WMQ 1ZLT 2CGW 1ZYS 1IA8 2BR1 2BRG 2WMS 2WMV 2X8I 2C3L 2XF0 2XEY
DescriptorSERINE/THREONINE-PROTEIN KINASE CHK1, 6-(1H-PYRAZOL-3-YL)-3-(1H-PYRAZOL-4-YL)IMIDAZO[1,2-A]PYRAZINE, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordstransferase, dna repair, cell cycle
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus O14757
Total number of polymer chains1
Total molecular weight33666.64
Authors
Primary citation
Matthews, T.P.,Mchardy, T.,Klair, S.,Boxall, K.,Fisher, M.,Cherry, M.,Allen, C.E.,Addison, G.J.,Ellard, J.,Aherne, G.W.,Westwood, I.M.,Montfort, R.V.,Garrett, M.D.,Reader, J.C.,Collins, I.
Design and Evaluation of 3,6-Di(Hetero)Aryl Imidazo[1,2-A]Pyrazines as Inhibitors of Checkpoint and Other Kinases.
Bioorg.Med.Chem.Lett., 20:4045-, 2010
PubMed: 20561787 (PDB entries with the same primary citation)
DOI: 10.1016/J.BMCL.2010.05.096
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.25 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.234180.4%0.4%16.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report