Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2XF0

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0000077biological_processDNA damage checkpoint signaling
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE 4UB A 1271
ChainResidue
ALEU15
AHOH2045
AVAL23
AALA36
AGLU85
ATYR86
ACYS87
AGLY90
ALEU137
ASER147

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 1272
ChainResidue
ACYS57
AMET61
AGLU97

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 1273
ChainResidue
APRO103
ATYR157
AASN158
AEDO1274

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE EDO A 1274
ChainResidue
AGLY123
AILE124
AGLY125
AARG156
AASN158
AASN159
AEDO1273

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE EDO A 1275
ChainResidue
ATRP221
ALYS224
AHIS243
ALEU246

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAYGEVQlAvnrvteea..........VAVK
ChainResidueDetails
ALEU15-LYS38

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ItHrDIKpeNLLL
ChainResidueDetails
AILE126-LEU138

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP130

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
ALEU15
ALYS38

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER280

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231
ChainResidueDetails
ASER286

site_idSWS_FT_FI5
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:32357935
ChainResidueDetails
ALYS132

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon