2WMT

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Summary for 2WMT

Related2CGX 2C3J 2BRO 2BRB 2BRH 2CGV 1NVR 2C3K 2CGW 1ZLT 2BRN 2AYP 1ZYS 2CGU 1IA8 2BR1 2BRG 1NVS 2BRM 1NVQ 2C3L 2WMQ 2WMR 2WMU 2WMV 2WMW 2WMX 2WMS
DescriptorSERINE/THREONINE-PROTEIN KINASE CHK1, 2-(methylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-imidazol-4-ol (3 entities in total)
Functional Keywordsserine/threonine-protein kinase, polymorphism, phosphoprotein, ubl conjugation, isopeptide bond, checkpoint kinase, nucleotide-binding, serine/threonine kinase, dna damage, dna repair, atp-binding, transferase, chk1, kinase, nucleus, cytoplasm, cell cycle
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus O14757
Total number of polymer chains1
Total molecular weight33269.31
Authors
Primary citation
Matthews, T.P.,Klair, S.,Burns, S.,Boxall, K.,Cherry, M.,Fisher, M.,Westwood, I.M.,Walton, M.I.,Mchardy, T.,Cheung, K.-M.J.,Van Montfort, R.,Williams, D.,Aherne, G.W.,Garrett, M.D.,Reader, J.,Collins, I.
Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening.
J.Med.Chem., 52:4810-, 2009
PubMed: 19572549 (PDB entries with the same primary citation)
DOI: 10.1021/JM900314J
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.55 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2301500.5%10.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report