2WMR

Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors

Summary for 2WMR

• Entry DOI: 10.2210/pdb2wmr/pdb
• Related: 1IA8 1NVQ 1NVR 1NVS 1ZLT 1ZYS 2AYP 2BR1 2BRB 2BRG 2BRH 2BRM 2BRN 2BRO 2C3J 2C3K 2C3L 2CGU 2CGV 2CGW 2CGX 2WMQ 2WMS 2WMT 2WMU 2WMV 2WMW 2WMX
• Descriptor: SERINE/THREONINE-PROTEIN KINASE CHK1, 5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE (3 entities in total)
• Functional Keywords: serine/threonine-protein kinase, polymorphism, phosphoprotein, ubl conjugation, isopeptide bond, checkpoint kinase, nucleotide-binding, serine/threonine kinase, dna damage, dna repair, atp-binding, transferase, chk1, kinase, nucleus, cytoplasm, cell cycle
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus: O14757
• Total number of polymer chains: 1
• Total formula weight: 33249.25

Authors

Matthews, T.P.,Klair, S.,Burns, S.,Boxall, K.,Cherry, M.,Fisher, M.,Westwood, I.M.,Walton, M.I.,McHardy, T.,Cheung, K.-M.J.,Van Montfort, R.,Williams, D.,Aherne, G.W.,Garrett, M.D.,Reader, J.,Collins, I. (deposition date: 2009-07-03, release date: 2009-07-28, Last modification date: 2023-12-13)

• Primary citation: Matthews, T.P.,Klair, S.,Burns, S.,Boxall, K.,Cherry, M.,Fisher, M.,Westwood, I.M.,Walton, M.I.,Mchardy, T.,Cheung, K.-M.J.,Van Montfort, R.,Williams, D.,Aherne, G.W.,Garrett, M.D.,Reader, J.,Collins, I.; Identification of Inhibitors of Checkpoint Kinase 1 Through Template Screening.; J.Med.Chem., 52:4810-, 2009; PubMed: 19572549; DOI: 10.1021/JM900314J

Experimental method

X-RAY DIFFRACTION (2.43 Å)