2AYP
Crystal Structure of CHK1 with an Indol Inhibitor
Summary for 2AYP
Entry DOI | 10.2210/pdb2ayp/pdb |
Descriptor | Serine/threonine-protein kinase Chk1, (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE (2 entities in total) |
Functional Keywords | protein-inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 31403.11 |
Authors | Lin, N.-H.,Xia, P.,Kovar, P.,Chen, Z.,Zhang, H.,Rosenberg, S.H.,Sham, H.L. (deposition date: 2005-09-07, release date: 2006-09-12, Last modification date: 2024-02-14) |
Primary citation | Lin, N.-H.,Xia, P.,Kovar, P.,Park, C.,Chen, Z.,Zhang, H.,Rosenberg, S.H.,Sham, H.L. Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors Bioorg.Med.Chem.Lett., 16:421-426, 2006 Cited by PubMed: 16242328DOI: 10.1016/j.bmcl.2005.09.064 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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