2BQW

CRYSTAL STRUCTURE OF FACTOR XA IN COMPLEX WITH COMPOUND 45

Summary for 2BQW

• Entry DOI: 10.2210/pdb2bqw/pdb
• Related: 1C5M 1EZQ 1F0R 1F0S 1FAX 1FJS 1FXY 1G2L 1G2M 1HCG 1IOE 1IQE 1IQF 1IQG 1IQH 1IQI 1IQJ 1IQK 1IQL 1IQM 1IQN 1KSN 1KYE 1LPG 1LPK 1LPZ 1LQD 1MQ5 1MQ6 1MSX 1NFU 1NFW 1NFX 1NFY 1NL8 1P0S 1V3X 1XKA 1XKB 2BMG 2BOH 2BOK 2BQ6 2BQ7
• Descriptor: COAGULATION FACTOR X, FACTOR XA, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: blood coagulation, blood coagulation factor, calcium-binding, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hydrolase, hydroxylation, plasma, polymorphism, protein inhibitor complex, serine proteinase, serine protease, vitamin k, zymogen
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 2
• Total formula weight: 34331.34

Authors

Nazare, M.,Will, D.W.,Matter, H.,Schreuder, H.,Ritter, K.,Urmann, M.,Essrich, M.,Bauer, A.,Wagner, M.,Czech, J.,Laux, V.,Wehner, V. (deposition date: 2005-04-28, release date: 2006-04-26, Last modification date: 2023-12-13)

• Primary citation: Nazare, M.,Will, D.W.,Matter, H.,Schreuder, H.,Ritter, K.,Urmann, M.,Essrich, M.,Bauer, A.,Wagner, M.,Czech, J.,Lorenz, M.,Laux, V.,Wehner, V.; Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-Ray Crystallography.; J.Med.Chem., 48:4511-, 2005; PubMed: 15999990; DOI: 10.1021/JM0490540

Experimental method

X-RAY DIFFRACTION (2.95 Å)