1MQ5

Crystal Structure of 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]phenyl]-4-[(4-methyl-1-piperazinyl)methyl]-2-thiophenecarboxamide Complexed with Human Factor Xa

Summary for 1MQ5

• Entry DOI: 10.2210/pdb1mq5/pdb
• Related: 1EZQ 1F0R 1F0S 1FJS 1QL7 1QL9 1mq6
• Descriptor: COAGULATION FACTOR X HEAVY CHAIN, COAGULATION FACTOR X LIGHT CHAIN, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: protein inhibitor complex, coagulation cofactor, protease, blood clotting
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32660.37

Authors

Adler, M.,Whitlow, M. (deposition date: 2002-09-13, release date: 2003-01-28, Last modification date: 2017-10-11)

• Primary citation: Adler, M.,Kochanny, M.J.,Bin, Y.,Rumennik, G.,Light, D.L.,Biancalana, S.,Whitlow, M.; Crystal Structures of Two Potent Nonamidine Inhibitors Bound to Factor Xa; Biochemistry, 41:15514-15523, 2002; PubMed: 12501180; DOI: 10.1021/bi0264061

Experimental method

X-RAY DIFFRACTION (2.1 Å)