1LQD
CRYSTAL STRUCTURE OF FXA IN COMPLEX WITH 45.
Summary for 1LQD
Entry DOI | 10.2210/pdb1lqd/pdb |
Related | 1LPG 1LPK 1LPZ 1LQE |
Descriptor | Blood coagulation factor Xa, CALCIUM ION, 1-(3-CARBAMIMIDOYL-BENZYL)-4-METHYL-1H-INDOLE-2-CARBOXYLIC ACID 3,5-DIMETHYL-BENZYLAMIDE, ... (5 entities in total) |
Functional Keywords | protein-inhibitor complex, blood coagulation factor, serine proteinase, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00742 P00742 |
Total number of polymer chains | 2 |
Total formula weight | 44226.00 |
Authors | Schreuder, H.A.,Loenze, P.,Brachvogel, V.,Liesum, A. (deposition date: 2002-05-10, release date: 2003-05-10, Last modification date: 2011-07-13) |
Primary citation | Matter, H.,Defossa, E.,Heinelt, U.,Blohm, P.M.,Schneider, D.,Mueller, A.,Herok, S.,Schreuder, H.A.,Liesum, A.,Brachvogel, V.,Loenze, P.,Walser, A.,Al-Obeidi, F.,Wildgoose, P. Design and Quantitative Structure-Activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa J.Med.Chem., 45:2749-2769, 2002 Cited by PubMed: 12061878DOI: 10.1021/jm0111346 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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