1V3X
Factor Xa in complex with the inhibitor 1-[6-methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridin-2-yl] carbonyl-2-carbamoyl-4-(6-chloronaphth-2-ylsulphonyl)piperazine
Summary for 1V3X
Entry DOI | 10.2210/pdb1v3x/pdb |
Related | 1fax 1xka |
Descriptor | Coagulation factor X, HEAVY CHAIN, Coagulation factor X, LIGHT CHAIN, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00742 P00742 |
Total number of polymer chains | 2 |
Total formula weight | 32549.44 |
Authors | Suzuki, M. (deposition date: 2003-11-07, release date: 2004-11-07, Last modification date: 2023-10-25) |
Primary citation | Haginoya, N.,Kobayashi, S.,Komoriya, S.,Yoshino, T.,Suzuki, M.,Shimada, T.,Watanabe, K.,Hirokawa, Y.,Furugori, T.,Nagahara, T. Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 binding element J.Med.Chem., 47:5167-5182, 2004 Cited by PubMed: 15456260DOI: 10.1021/jm049884d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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