1OKW

Cyclin A binding groove inhibitor Ac-Arg-Arg-Leu-Asn-(m-Cl-Phe)-NH2

Summary for 1OKW

Related1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H06 1H07 1H08 1H0U 1H0V 1H0W 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1OGU 1OI9 1OIQ 1OIR 1OIT 1OIU 1OIY 1OKU 1OKV 1P2A 1P5E 1PKD 1QMZ 1OL1 1OL2
DescriptorCELL DIVISION PROTEIN KINASE 2, CYCLIN A2, ACE-ARG-ARG-LEU-ASN-FCL-NH2, ... (4 entities in total)
Functional Keywordscell cycle, complex(kinase-cyclin), cyclin a, ligand exchange, peptidomimetics, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Nucleus  P20248
Total number of polymer chains6
Total molecular weight129218.66
Authors
Kontopidis, G.,Andrews, M.,McInnes, C.,Cowan, A.,Powers, H.,Innes, L.,Plater, A.,Griffiths, G.,Paterson, D.,Zheleva, D.,Lane, D.,Green, S.,Walkinshaw, M.,Fischer, P. (deposition date: 2003-07-31, release date: 2003-12-11, Last modification date: 2016-12-21)
Primary citation
Kontopidis, G.,Andrews, M.,Mcinnes, C.,Cowan, A.,Powers, H.,Innes, L.,Plater, A.,Griffiths, G.,Paterson, D.,Zheleva, D.,Lane, D.,Green, S.,Walkinshaw, M.,Fischer, P.
Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange
Structure, 11:1537-, 2003
PubMed: 14656438 (PDB entries with the same primary citation)
DOI: 10.1016/J.STR.2003.11.006
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.260302.1%12.9%3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report