1OKV

Cyclin A binding groove inhibitor H-Arg-Arg-Leu-Ile-Phe-NH2

1OKV の概要

関連するPDBエントリー1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H06 1H07 1H08 1H0U 1H0V 1H0W 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1OGU 1OI9 1OIQ 1OIR 1OIT 1OIU 1OIY 1OKU 1OKW 1OL1 1OL2 1P2A 1P5E 1PKD 1QMZ
分子名称CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, H-ARG-ARG-LEU-ILE-PHE-NH2, ... (4 entities in total)
機能のキーワードkinase-cyclin complex, cyclin a, inhibitor, ligand exchange, drug design, peptidomimetics, cell cycle, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
由来する生物種HOMO SAPIENS (HUMAN)
詳細
細胞内の位置Cytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Nucleus  P20248
ポリマー鎖数6
分子量合計129095.8
構造登録者
主引用文献
Kontopidis, G.,Andrews, M.,Mcinnes, C.,Cowan, A.,Powers, H.,Innes, L.,Plater, A.,Griffiths, G.,Paterson, D.,Zheleva, D.,Lane, D.,Green, S.,Walkinshaw, M.,Fischer, P.
Insights Into Cyclin Groove Recognition. Complex Crystal Structures and Inhibitor Design Through Ligand Exchange
Structure, 11:1537-, 2003
PubMed: 14656438 (主引用文献が同じPDBエントリー)
DOI: 10.1016/J.STR.2003.11.006
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.4 Å)
?

構造検証レポート

ClashscoreRamachandran outliersSidechain outliers171.8%12.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード