1MF8

Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin

Summary for 1MF8

Entry DOI	10.2210/pdb1mf8/pdb
Related	1AUI 1BCK 1C5F 1CSA 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1CYA 1CYB 1CYN 1IKF 1M63 1MIK 1QNG 1QNH 1XQ7 2ESL 2OJU 2POY 2RMA 2RMB 2RMC 2WFJ 2X2C 2X7K 2Z6W 3BO7 3CYS 3EOV
Related PRD ID	PRD_000142
Descriptor	CALMODULIN-DEPENDENT CALCINEURIN A SUBUNIT, ALPHA ISOFORM, CALCINEURIN B SUBUNIT ISOFORM 1, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, ... (6 entities in total)
Functional Keywords	hydrolase-isomerase-immunosuppressant complex, calcineurin-cyclophilin-cyclosporin complex, cyclosporin a, immunosuppressant, hydrolase, isomerase, hydrolase/isomerase/immunosuppressant
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Nucleus (By similarity): Q08209 Cytoplasm: P62937
Total number of polymer chains	4
Total formula weight	81605.95
Authors	Jin, L.,Harrison, S.C. (deposition date: 2002-08-09, release date: 2002-10-16, Last modification date: 2012-12-12)
Primary citation	Jin, L.,Harrison, S.C. Crystal Structure of Human Calcineurin Complexed with Cyclosporin a and Human Cyclophilin Proc.Natl.Acad.Sci.USA, 99:13522-, 2002 Cited by PubMed: 12357034 DOI: 10.1073/PNAS.212504399 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation