2ESL

Human Cyclophilin C in Complex with Cyclosporin A

Summary for 2ESL

Related1BCK 1C5F 1CSA 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1CYA 1CYB 1CYN 1M63 1MF8 1MIK 1QNG 1QNH 1XQ7 2OJU 2POY 2RMA 2RMB 2RMC 2WFJ 2X2C 2X7K 2Z6W 3BO7 3CYS 3EOV
Related PRD IDPRD_000142
DescriptorPeptidyl-prolyl cis-trans isomerase C, CYCLOSPORIN A, CALCIUM ION, ... (6 entities in total)
Functional Keywordsisomerase-immunosuppressant complex, cyclophilin-cyclosporin complex, cyclosporin a, immunosupressant, cyclophilin, sgc, structural genomics, structural genomics consortium, isomerase/immunosuppressant
Biological sourceHomo sapiens (Human)
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Cellular locationCytoplasm P45877
Total number of polymer chains12
Total molecular weight131405.43
Authors
Primary citation
Davis, T.L.,Walker, J.R.,Campagna-Slater, V.,Finerty, P.J.,Paramanathan, R.,Bernstein, G.,MacKenzie, F.,Tempel, W.,Ouyang, H.,Lee, W.H.,Eisenmesser, E.Z.,Dhe-Paganon, S.
Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases.
PLoS Biol., 8:e1000439-e1000439, 2010
PubMed: 20676357 (PDB entries with the same primary citation)
DOI: 10.1371/journal.pbio.1000439
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.227804.2%3.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2esl
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Molmil generated image of 2esl
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Molmil generated image of 2esl
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More Biological unit images

Molmil generated image of 2esl
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Molmil generated image of 2esl
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Molmil generated image of 2esl
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2esl.pdb10.gz [69.86 KB])
Coordinate files for Biological unit (2esl.pdb8.gz [101.85 KB])
Coordinate files for Biological unit (2esl.pdb7.gz [195.51 KB])
Coordinate files for Biological unit (2esl.pdb6.gz [36.26 KB])
Coordinate files for Biological unit (2esl.pdb2.gz [37.64 KB])
Coordinate files for Biological unit (2esl.pdb1.gz [37.9 KB])
Coordinate files for Biological unit (2esl.pdb12.gz [68.08 KB])
Coordinate files for Biological unit (2esl.pdb11.gz [68.68 KB])
Coordinate files for Biological unit (2esl.pdb4.gz [37.46 KB])
Coordinate files for Biological unit (2esl.pdb5.gz [36.08 KB])
Coordinate files for Biological unit (2esl.pdb9.gz [99.26 KB])
Coordinate files for Biological unit (2esl.pdb3.gz [37.02 KB])