2ESL

Human Cyclophilin C in Complex with Cyclosporin A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000413	biological_process	protein peptidyl-prolyl isomerization
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0006457	biological_process	protein folding
B	0000413	biological_process	protein peptidyl-prolyl isomerization
B	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
B	0006457	biological_process	protein folding
C	0000413	biological_process	protein peptidyl-prolyl isomerization
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0006457	biological_process	protein folding
D	0000413	biological_process	protein peptidyl-prolyl isomerization
D	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
D	0006457	biological_process	protein folding
E	0000413	biological_process	protein peptidyl-prolyl isomerization
E	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
E	0006457	biological_process	protein folding
F	0000413	biological_process	protein peptidyl-prolyl isomerization
F	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
F	0006457	biological_process	protein folding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 1

Chain	Residue
A	ASP93
B	ASP93
C	ASP93

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA D 2

Chain	Residue
D	ASP93
E	ASP93
F	ASP93

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA F 3

Chain	Residue
E	GLU115
F	GLU68
F	GLU77

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 4

Chain	Residue
A	HIS174
A	HOH2001
B	HIS174
C	HIS174

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 5

Chain	Residue
D	HIS174
D	HOH2001
E	HIS174
F	HIS174

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 6

Chain	Residue
A	ASP168
A	GLY169
A	MET170
A	HOH2002
A	HOH2003
A	HOH2004
B	GLN179
B	ALA180

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 7

Chain	Residue
B	ASP168
B	GLY169
B	MET170
B	HOH2001
B	HOH2002
B	HOH2003
C	GLN179
C	ALA180

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 8

Chain	Residue
A	GLN179
A	ALA180
A	HOH2126
C	ASP168
C	GLY169
C	MET170
C	HOH2001
C	HOH2002

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 9

Chain	Residue
D	ASP168
D	GLY169
D	MET170
D	HOH2002
D	HOH2003
E	GLN179
E	ALA180

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 E 10

Chain	Residue
E	ASP168
E	GLY169
E	MET170
E	HOH2001
E	HOH2002
F	GLN179
F	ALA180
F	HOH2069

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 11

Chain	Residue
D	GLN179
D	ALA180
D	HOH2124
F	ASP168
F	GLY169
F	MET170
F	HOH2001

---

site_id	BC3
Number of Residues	25
Details	BINDING SITE FOR CHAIN I OF CYCLOSPORIN A

Chain	Residue
A	ARG89
A	PHE94
A	GLN97
A	GLY106
A	THR107
A	ALA135
A	ASN136
A	ALA137
A	GLN145
A	PHE147
A	TRP155
A	HIS160
E	PRO139
E	TRP155
I	HOH2001
I	HOH2002
I	HOH2003
I	HOH2004
I	HOH2005
I	HOH2006
I	HOH2007
I	HOH2008
M	MLE3
M	MLE10
M	ALA11

---

site_id	BC4
Number of Residues	21
Details	BINDING SITE FOR CHAIN J OF CYCLOSPORIN A

Chain	Residue
B	HOH2061
D	TRP155
J	HOH2002
J	HOH2003
J	HOH2004
J	HOH2007
J	HOH2008
L	BMT5
L	MLE10
L	ALA11
B	ARG89
B	PHE94
B	GLN97
B	GLY106
B	ALA135
B	ASN136
B	ALA137
B	GLN145
B	PHE147
B	TRP155
B	HIS160

---

site_id	BC5
Number of Residues	21
Details	BINDING SITE FOR CHAIN K OF CYCLOSPORIN A

Chain	Residue
C	ARG89
C	PHE94
C	GLN97
C	GLY106
C	ALA135
C	ASN136
C	ALA137
C	GLN145
C	PHE147
C	TRP155
C	HIS160
F	TRP155
K	HOH2001
K	HOH2002
K	HOH2003
K	HOH2004
K	HOH2005
K	HOH2006
N	MLE3
N	BMT5
N	MLE10

---

site_id	BC6
Number of Residues	18
Details	BINDING SITE FOR CHAIN L OF CYCLOSPORIN A

Chain	Residue
B	TRP155
D	ARG89
D	PHE94
D	GLN97
D	GLY106
D	ALA135
D	ASN136
D	GLN145
D	PHE147
D	TRP155
D	HIS160
J	MLE3
J	MLE10
J	HOH2007
L	HOH2001
L	HOH2002
L	HOH2003
L	HOH2004

---

site_id	BC7
Number of Residues	23
Details	BINDING SITE FOR CHAIN M OF CYCLOSPORIN A

Chain	Residue
A	PRO139
A	TRP155
A	LYS159
E	ARG89
E	PHE94
E	GLN97
E	GLY106
E	ALA135
E	ASN136
E	GLN145
E	PHE147
E	TRP155
E	HIS160
I	MLE3
I	BMT5
I	MLE10
I	ALA11
I	HOH2007
M	HOH2001
M	HOH2002
M	HOH2003
M	HOH2004
M	HOH2005

---

site_id	BC8
Number of Residues	22
Details	BINDING SITE FOR CHAIN N OF CYCLOSPORIN A

Chain	Residue
C	ALA137
C	TRP155
F	ARG89
F	PHE94
F	GLN97
F	GLY106
F	THR107
F	ALA135
F	ASN136
F	GLN145
F	PHE147
F	TRP155
F	HIS160
K	BMT5
K	MLE10
K	ALA11
K	HOH2005
N	HOH2001
N	HOH2003
N	HOH2004
N	HOH2005
N	HOH2006

---

Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgSkFHRVIkdFMiQGG

Chain	Residue	Details
A	TYR82-GLY99

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	942
Details	Domain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---