1M63

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes

Summary for 1M63
Related1BCK 1C5F 1CSA 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1CYA 1CYB 1CYN 1IKF 1MF8 1MIK 1QNG 1QNH 1XQ7 2ESL 2OJU 2POY 2RMA 2RMB 2RMC 2WFJ 2X2C 2X7K 2Z6W 3BO7 3CYS 3EOV
Related PRD IDPRD_000142
DescriptorSERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT, ALPHA ISOFORM, CALCINEURIN B SUBUNIT ISOFORM 1, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A, ... (7 entities in total)
Functional Keywordshydrolase-isomerase-immunosuppressant complex, immunophilin, calcineurin, cyclosporin a, immunosuppressant, cyclophilin, hydrolase/isomerase/immunosuppressant
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationCell membrane : Q08209
Cytoplasm, cytosol : P63098
Cytoplasm : P62937
Total number of polymer chains8
Total formula weight163213.10
Authors
Huai, Q.,Kim, H.-Y.,Liu, Y.,Zhao, Y.,Mondragon, A.,Liu, J.O.,Ke, H. (deposition date: 2002-07-12, release date: 2002-09-25, Last modification date: 2017-11-01)
Primary citationHuai, Q.,Ke, H.,Kim, H.-Y.,Liu, J.O.,Liu, Y.,Mondragon, A.,Zhao, Y.
Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes
Proc.Natl.Acad.Sci.USA, 99:12037-, 2002
PubMed: 12218175
DOI: 110.1073/PNAS.192206699
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation
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PDB entries from 2021-06-23