1M63
Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | SERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT, ALPHA ISOFORM | polymer | 372 | 42876.1 | 2 | UniProt (Q08209) Pfam (PF00149) | HOMO SAPIENS (HUMAN) | CALMODULIN-DEPENDENT CALINEURIN A SUBUNIT, ALPHA ISOFORM, CAM-PRP SUBUNIT |
| 2 | B, F (B, F) | CALCINEURIN B SUBUNIT ISOFORM 1 | polymer | 169 | 19191.7 | 2 | UniProt (P63098) Pfam (PF13499) | HOMO SAPIENS (HUMAN) | PROTEIN PHOSPHATASE 2B REGULATORY SUBUNIT 1, PROTEIN PHOSPHATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM 1 |
| 3 | C, G (C, G) | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A | polymer | 165 | 18036.5 | 2 | UniProt (P62937) Pfam (PF00160) | HOMO SAPIENS (HUMAN) | PPIASE, ROTAMASE, CYCLOPHILIN A, CYCLOSPORIN A- BINDING PROTEIN |
| 4 | D, H (D, H) | CYCLOSPORIN A | polymer | 11 | 1220.6 | 2 | NOR (NOR00033) BIRD (PRD_000142) | TOLYPOCLADIUM INFLATUM | CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE |
| 5 | I, O (A, E) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | J, P (A, E) | FE (III) ION | non-polymer | 55.8 | 2 | Chemie (FE) | |||
| 7 | K, L, M, N, Q... (B, F) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 162650.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 563.1 | |
| All* | Total formula weight | 163213.1 |
