2X2C

acetyl-CypA:cyclosporine complex

Summary for 2X2C

• Entry DOI: 10.2210/pdb2x2c/pdb
• Related: 1AK4 1AWR 1AWS 1AWT 1AWU 1AWV 1BCK 1C5F 1CSA 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1CYA 1CYB 1CYN 1FGL 1IKF 1M63 1M9C 1M9D 1M9E 1M9F 1M9X 1M9Y 1MF8 1MIK 1NMK 1OCA 1QNG 1QNH 1RMH 1VBS 1VBT 1W8L 1W8M 1W8V 1XQ7 2ALF 2CPL 2CYH 2ESL 2OJU 2POY 2RMA 2RMB 2RMC 2WFJ 2X25 2X2A 2X2C 2X2D 2X7K 2Z6W 3BO7 3CYS 3EOV 4CYH 5CYH
• Related PRD ID: PRD_000142
• Descriptor: CYCLOSPORIN A, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A (3 entities in total)
• Functional Keywords: isomerase-immunosuppressant complex, cyclophilin-cyclosporin complex, cyclosporin a, immunosuppressant, isomerase, isomerase/immunosuppressant
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Cytoplasm : P62937
• Total number of polymer chains: 10
• Total formula weight: 96490.78

Authors

Lammers, M.,Neumann, H.,Chin, J.W.,James, L.C. (deposition date: 2010-01-12, release date: 2010-03-23, Last modification date: 2018-05-02)

• Primary citation: Lammers, M.,Neumann, H.,Chin, J.W.,James, L.C.; Acetylation Regulates Cyclophilin a Catalysis, Immunosuppression and HIV Isomerisation; Nat.Chem.Biol., 6:331-, 2010; PubMed: 20364129; DOI: 10.1038/NCHEMBIO.342

Experimental method

X-RAY DIFFRACTION (2.41 Å)