2RMA
Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A
Summary for 2RMA
Entry DOI | 10.2210/pdb2rma/pdb |
Related | 1BCK 1C5F 1CSA 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1CYA 1CYB 1CYN 1M63 1MF8 1MIK 1QNG 1QNH 1XQ7 2ESL 2OJU 2POY 2RMB 2RMC 2WFJ 2X2C 2X7K 2Z6W 3BO7 3CYS 3EOV |
Related PRD ID | PRD_000142 |
Descriptor | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE, CYCLOSPORIN A (3 entities in total) |
Functional Keywords | isomerase-immunosuppressant complex, cyclophilin-cyclosporin complex, cyclosporin a, immunosuppressant, cyclophilin, isomerase/immunosuppressant |
Biological source | HOMO SAPIENS More |
Cellular location | Cytoplasm : P62937 |
Total number of polymer chains | 20 |
Total formula weight | 192571.29 |
Authors | Ke, H.,Mayrose, D. (deposition date: 1994-01-07, release date: 1995-02-07, Last modification date: 2017-11-01) |
Primary citation | Ke, H.,Mayrose, D.,Belshaw, P.J.,Alberg, D.G.,Schreiber, S.L.,Chang, Z.Y.,Etzkorn, F.A.,Ho, S.,Walsh, C.T. Crystal Structures of Cyclophilin a Complexed with Cyclosporin a and N-Methyl-4-[(E)-2-Butenyl]-4,4-Dimethylthreonine Cyclosporin A. Structure, 2:33-, 1994 Cited by PubMed Abstract: Cyclophilin (CyP) is a ubiquitious intracellular protein that binds the immunosuppressive drug cyclosporin A (CsA). CyP-CsA forms a ternary complex with calcineurin and thereby inhibits T-cell activation. CyP also has enzymatic activity, catalyzing the cis-trans isomerization of peptidyl-prolyl amide bonds. PubMed: 8075981DOI: 10.1016/S0969-2126(00)00006-X PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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