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2RMA

Crystal structures of cyclophilin A complexed with cyclosporin A and N-methyl-4-[(E)-2-butenyl]-4,4-dimethylthreonine cyclosporin A

Summary for 2RMA
Entry DOI10.2210/pdb2rma/pdb
Related1BCK 1C5F 1CSA 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1CYA 1CYB 1CYN 1M63 1MF8 1MIK 1QNG 1QNH 1XQ7 2ESL 2OJU 2POY 2RMB 2RMC 2WFJ 2X2C 2X7K 2Z6W 3BO7 3CYS 3EOV
Related PRD IDPRD_000142
DescriptorPEPTIDYL-PROLYL CIS-TRANS ISOMERASE, CYCLOSPORIN A (3 entities in total)
Functional Keywordsisomerase-immunosuppressant complex, cyclophilin-cyclosporin complex, cyclosporin a, immunosuppressant, cyclophilin, isomerase/immunosuppressant
Biological sourceHOMO SAPIENS
More
Cellular locationCytoplasm : P62937
Total number of polymer chains20
Total formula weight192571.29
Authors
Ke, H.,Mayrose, D. (deposition date: 1994-01-07, release date: 1995-02-07, Last modification date: 2017-11-01)
Primary citationKe, H.,Mayrose, D.,Belshaw, P.J.,Alberg, D.G.,Schreiber, S.L.,Chang, Z.Y.,Etzkorn, F.A.,Ho, S.,Walsh, C.T.
Crystal Structures of Cyclophilin a Complexed with Cyclosporin a and N-Methyl-4-[(E)-2-Butenyl]-4,4-Dimethylthreonine Cyclosporin A.
Structure, 2:33-, 1994
Cited by
PubMed Abstract: Cyclophilin (CyP) is a ubiquitious intracellular protein that binds the immunosuppressive drug cyclosporin A (CsA). CyP-CsA forms a ternary complex with calcineurin and thereby inhibits T-cell activation. CyP also has enzymatic activity, catalyzing the cis-trans isomerization of peptidyl-prolyl amide bonds.
PubMed: 8075981
DOI: 10.1016/S0969-2126(00)00006-X
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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