2Z6W

Crystal structure of human cyclophilin D in complex with cyclosporin A

Summary for 2Z6W

Entry DOI	10.2210/pdb2z6w/pdb
Related	1BCK 1C5F 1CSA 1CWA 1CWB 1CWC 1CWF 1CWH 1CWI 1CWJ 1CWK 1CWL 1CWM 1CWO 1CYA 1CYB 1CYN 1IKF 1M63 1MF8 1MIK 1QNG 1QNH 1XQ7 2ESL 2OJU 2POY 2RMA 2RMB 2RMC 2WFJ 2X2C 2X7K 3BO7 3CYS 3EOV
Related PRD ID	PRD_000142
Descriptor	PEPTIDYL-PROLYL CIS-TRANS ISOMERASE, CYCLOSPORIN A, CITRIC ACID, ... (4 entities in total)
Functional Keywords	isomerase-immunosuppressant complex, cyclophilin-cyclosporin complex, cyclosporin a, immunosuppressant, cyclophilin d, isomerase/immunosuppressant
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Mitochondrion matrix: P30405
Total number of polymer chains	4
Total formula weight	38200.02
Authors	Kajitani, K.,Fujihashi, M.,Kobayashi, Y.,Shimizu, S.,Tsujimoto, Y.,Miki, K. (deposition date: 2007-08-09, release date: 2008-04-29, Last modification date: 2023-11-15)
Primary citation	Kajitani, K.,Fujihashi, M.,Kobayashi, Y.,Shimizu, S.,Tsujimoto, Y.,Miki, K. Crystal Structure of Human Cyclophilin D in Complex with its Inhibitor, Cyclosporin a at 0.96-A Resolution. Proteins, 70:1635-, 2008 Cited by PubMed: 18076075 DOI: 10.1002/PROT.21855 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.96 Å)

Structure validation