2Z6W
Crystal structure of human cyclophilin D in complex with cyclosporin A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE | polymer | 165 | 17783.3 | 2 | UniProt (P30405) Pfam (PF00160) In PDB | HOMO SAPIENS (HUMAN) | PPIASE, ROTAMASE, CYCLOPHILIN D |
| 2 | M, N | CYCLOSPORIN A | polymer | 11 | 1220.6 | 2 | NOR (NOR00033) BIRD (PRD_000142) | TOLYPOCLADIUM INFLATUM | CICLOSPORIN, CICLOSPORINE |
| 3 | A | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 4 | water | water | 18.0 | 524 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 165 (UniProt: P30405)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Ile 133 | Lys 175 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 38007.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 192.1 | |
| All* | Total formula weight | 38200.0 |
