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2Z6W

Crystal structure of human cyclophilin D in complex with cyclosporin A

Functional Information from GO Data
ChainGOidnamespacecontents
A0000413biological_processprotein peptidyl-prolyl isomerization
A0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
A0006457biological_processprotein folding
B0000413biological_processprotein peptidyl-prolyl isomerization
B0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
B0006457biological_processprotein folding
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE CIT A 3001
ChainResidue
AGLY50
AHOH2257
AHOH2258
ASER51
ATHR52
AHIS70
AGLY80
ASER81
AARG82
ALYS155
AHOH2149

site_idAC2
Number of Residues30
DetailsBINDING SITE FOR CHAIN M OF CYCLOSPORIN A
ChainResidue
AARG55
APHE60
AGLN63
AGLY72
AALA101
AASN102
AALA103
AGLN111
APHE113
ATRP121
AHIS126
AHOH2135
BLEU5
BSER81
BALA103
BGLU134
BLEU164
BHOH2161
BHOH2199
BHOH2244
MHOH2001
MHOH2002
MHOH2003
MHOH2004
MHOH2005
MHOH2006
MHOH2007
MHOH2008
MHOH2009
MHOH2010

site_idAC3
Number of Residues25
DetailsBINDING SITE FOR CHAIN N OF CYCLOSPORIN A
ChainResidue
AGLY104
AHOH2197
BARG37
BGLU43
BARG55
BPHE60
BGLN63
BGLY72
BALA101
BASN102
BGLN111
BPHE113
BTRP121
BHIS126
BGLN163
BLEU164
BSER165
BHOH2110
BHOH2124
BHOH2218
NHOH2001
NHOH2005
NHOH2006
NHOH2007
NHOH2008

Functional Information from PROSITE/UniProt
site_idPS00170
Number of Residues18
DetailsCSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgStFHRVIpsFMcQAG
ChainResidueDetails
ATYR48-GLY65

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q99KR7
ChainResidueDetails
ALYS25
BLYS25

site_idSWS_FT_FI2
Number of Residues6
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q99KR7
ChainResidueDetails
ALYS44
AILE133
ALYS148
BLYS44
BILE133
BLYS148

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q99KR7
ChainResidueDetails
ALYS125
BLYS125

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q99KR7
ChainResidueDetails
ACYS161
BCYS161

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PDB entries from 2024-10-30

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