1MF8
Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CALMODULIN-DEPENDENT CALCINEURIN A SUBUNIT, ALPHA ISOFORM | polymer | 373 | 42770.6 | 1 | UniProt (Q08209) Pfam (PF00149) | HOMO SAPIENS (HUMAN) | SERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM, CAM-PRP CATALYTIC SUBUNIT |
| 2 | B (B) | CALCINEURIN B SUBUNIT ISOFORM 1 | polymer | 170 | 19322.9 | 1 | UniProt (P63098) Pfam (PF13499) | HOMO SAPIENS (HUMAN) | PROTEIN PHOSPHATASE 2B REGULATORY SUBUNIT 1, PROTEIN PHOSPHATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM 1 |
| 3 | C (C) | PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A | polymer | 165 | 18036.5 | 1 | UniProt (P62937) Pfam (PF00160) | HOMO SAPIENS (HUMAN) | PPIASE, ROTAMASE, CYCLOPHILIN A |
| 4 | D (D) | CYCLOSPORIN A | polymer | 11 | 1220.6 | 1 | NOR (NOR00033) BIRD (PRD_000142) | TOLYPOCLADIUM INFLATUM | CYCLOSPORINE, CICLOSPORIN, CICLOSPORINE |
| 5 | E (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 6 | F, G, H, I (B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 81350.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 255.3 | |
| All* | Total formula weight | 81606.0 |
