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1JLB

CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE

Summary for 1JLB
Entry DOI10.2210/pdb1jlb/pdb
Related1C0T 1C0U 1C1B 1C1C 1DTQ 1DTT 1EP4 1FK9 1FKO 1FKP 1JKH 1JLA 1JLC 1JLE 1JLF 1JLG 1JLQ 1KLM 1REV 1RT1 1RT2 1RT3 1RT4 1RT5 1RT6 1RT7 1RTH 1RTI 1RTJ 1VRT 1VRU
DescriptorHIV-1 RT A-chain, HIV-1 RT B-chain, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE (3 entities in total)
Functional Keywordshiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, nevirapine, drug resistance mutations, drug design, transferase
Biological sourceHIV-1 M:B_HXB2R
More
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585
Total number of polymer chains2
Total formula weight116140.23
Authors
Ren, J.,Nichols, C.,Bird, L.,Chamberlain, P.,Weaver, K.,Short, S.,Stuart, D.I.,Stammers, D.K. (deposition date: 2001-07-16, release date: 2001-10-03, Last modification date: 2022-12-21)
Primary citationRen, J.,Nichols, C.,Bird, L.,Chamberlain, P.,Weaver, K.,Short, S.,Stuart, D.I.,Stammers, D.K.
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
J.Mol.Biol., 312:795-805, 2001
Cited by
PubMed: 11575933
DOI: 10.1006/jmbi.2001.4988
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

217705

건을2024-03-27부터공개중

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