1JLB

CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	HIV-1 RT A-chain	polymer	560	64534.9	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	HIV-1 M:B_HXB2R
2	B	HIV-1 RT B-chain	polymer	440	51339.0	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	HIV-1 M:B_HXB2R
3	A	11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE	non-polymer		266.3	1	Chemie (NVP)

Sequence modifications

A: 1 - 560 (UniProt: P04585)

PDB	External Database	Details
Cys 181	Tyr 336	engineered mutation
Csd 280	Cys 435	modified residue

B: 1 - 440 (UniProt: P04585)

PDB	External Database	Details
Cys 181	Tyr 336	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	115873.9
Non-Polymers*	Number of molecules	1
	Total formula weight	266.3
All*	Total formula weight	116140.2

*Water molecules are not included.