1JKH
CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)
Summary for 1JKH
Entry DOI | 10.2210/pdb1jkh/pdb |
Related | 1C0T 1C0U 1C1B 1C1C 1DTQ 1DTT 1EP4 1FK9 1FKO 1FKP 1JLA 1JLB 1JLC 1JLE 1JLF 1JLG 1JLQ 1KLM 1REV 1RT1 1RT2 1RT3 1RT4 1RT5 1RT6 1RT7 1RTH 1RTI 1RTJ 1VRT 1VRU |
Descriptor | HIV-1 RT, A-CHAIN, HIV-1 RT, B-CHAIN, (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE, ... (4 entities in total) |
Functional Keywords | hiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, dmp-266, efavirenz, drug resistance mutations, drug design, transferase |
Biological source | HIV-1 M:B_HXB2R More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 116189.61 |
Authors | Ren, J.,Nichols, C.,Bird, L.,Chamberlain, P.,Weaver, K.,Short, S.,Stuart, D.I.,Stammers, D.K. (deposition date: 2001-07-12, release date: 2001-10-03, Last modification date: 2022-12-21) |
Primary citation | Ren, J.,Nichols, C.,Bird, L.,Chamberlain, P.,Weaver, K.,Short, S.,Stuart, D.I.,Stammers, D.K. Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors. J.Mol.Biol., 312:795-805, 2001 Cited by PubMed: 11575933DOI: 10.1006/jmbi.2001.4988 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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