1JKH

CRYSTAL STRUCTURE OF Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DMP-266(EFAVIRENZ)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	HIV-1 RT, A-CHAIN	polymer	560	64534.9	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	HIV-1 M:B_HXB2R
2	B	HIV-1 RT, B-CHAIN	polymer	440	51339.0	1	UniProt (P04585) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	HIV-1 M:B_HXB2R
3	A	(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE	non-polymer		315.7	1	Chemie (EFZ)
4		water	water		18.0	123	Chemie (HOH)

Sequence modifications

A: 1 - 560 (UniProt: P04585)

PDB	External Database	Details
Cys 181	Tyr 336	modified residue
Csd 280	Cys 435	modified residue

B: 1 - 440 (UniProt: P04585)

PDB	External Database	Details
Cys 181	Tyr 336	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	115873.9
Non-Polymers*	Number of molecules	1
	Total formula weight	315.7
All*	Total formula weight	116189.6

*Water molecules are not included.