6NJS
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STAT3 CORE IN COMPLEX WITH COMPOUND SD36
Descriptor:Signal transducer and activator of transcription 3, [(2-{[(5S,8S,10aR)-3-acetyl-8-({(2S)-5-amino-1-[(diphenylmethyl)amino]-1,5-dioxopentan-2-yl}carbamoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl}-1H-indol-5-yl)(difluoro)methyl]phosphonic acid (non-preferred name)
Authors:Meagher, J.L., Stuckey, J.A.
Deposit date:2019-01-04
Release date:2019-12-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
Cancer Cell, 36, 2019
6NUQ
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STAT3 CORE IN COMPLEX WITH COMPOUND SI109
Descriptor:Signal transducer and activator of transcription 3, [(2-{[(5S,8S,10aR)-3-acetyl-8-({(2S)-5-amino-1-[(diphenylmethyl)amino]-1,5-dioxopentan-2-yl}carbamoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl}-1H-indol-5-yl)(difluoro)methyl]phosphonic acid (non-preferred name)
Authors:Meagher, J.L., Stuckey, J.A.
Deposit date:2019-02-01
Release date:2019-12-04
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
Cancer Cell, 36, 2019
4ZIA
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CRYSTAL STRUCTURE OF STAT3 N-TERMINAL DOMAIN
Descriptor:Signal transducer and activator of transcription 3, NICKEL (II) ION, FORMIC ACID, ...
Authors:Hu, T., Chopra, R.
Deposit date:2015-04-28
Release date:2015-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity.
Mol.Cell.Biol., 35, 2015
3CWG
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UNPHOSPHORYLATED MOUSE STAT3 CORE FRAGMENT
Descriptor:Signal transducer and activator of transcription 3
Authors:Ren, Z., Mao, X., Mertens, C., Krishnaraj, R., Qin, J., Mandal, P.K., Romanowshi, M.J., McMurray, J.S.
Deposit date:2008-04-21
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of unphosphorylated STAT3 core fragment.
Biochem.Biophys.Res.Commun., 374, 2008
6TLC
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UNPHOSPHORYLATED HUMAN STAT3 IN COMPLEX WITH MS3-6 MONOBODY
Descriptor:Signal transducer and activator of transcription 3, Monobody
Authors:La Sala, G., Lau, K., Reynaud, A., Pojer, F., Hantschel, O.
Deposit date:2019-12-02
Release date:2020-07-22
Last modified:2020-08-26
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains.
Nat Commun, 11, 2020
6QHD
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LYSINE ACETYLATED AND TYROSINE PHOSPHORYLATED STAT3 IN A COMPLEX WITH DNA
Descriptor:Signal transducer and activator of transcription 3, DNA (5'-D(*AP*AP*GP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*TP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3')
Authors:Arbely, E., Belo, Y., Shahar, A., Zarivach, R.
Deposit date:2019-01-16
Release date:2019-06-19
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine.
Biochim Biophys Acta Gen Subj, 1863, 2019
4E68
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UNPHOSPHORYLATED STAT3B CORE PROTEIN BINDING TO DSDNA
Descriptor:DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), Signal transducer and activator of transcription 3
Authors:Collie, G.W., Parkinson, G.N., Shah, R.
Deposit date:2012-03-15
Release date:2013-03-06
Last modified:2013-04-10
Method:X-RAY DIFFRACTION (2.585 Å)
Cite:Observation of unphosphorylated STAT3 core protein binding to target dsDNA by PEMSA and X-ray crystallography.
Febs Lett., 587, 2013
5U5S
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SOLUTION STRUCTURES OF BRD2 SECOND BROMODOMAIN IN COMPLEX WITH STAT3 PEPTIDE
Descriptor:Bromodomain-containing protein 2, Stat3 peptide
Authors:Zeng, L., Zhou, M.-M.
Deposit date:2016-12-07
Release date:2017-03-22
Last modified:2019-12-04
Method:SOLUTION NMR
Cite:Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
Mol. Cell, 65, 2017
6DLG
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CRYSTAL STRUCTURE OF A SHIP1 SURFACE ENTROPY REDUCTION MUTANT
Descriptor:Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, ISOPROPYL ALCOHOL
Authors:Gardill, B.R., Cheung, S.T., Mui, A.L., Van Petegem, F.
Deposit date:2018-06-01
Release date:2019-06-05
Last modified:2020-06-17
Method:X-RAY DIFFRACTION (1.499 Å)
Cite:Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes
Biorxiv, 2020
1BG1
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TRANSCRIPTION FACTOR STAT3B/DNA COMPLEX
Descriptor:DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), PROTEIN (TRANSCRIPTION FACTOR STAT3B)
Authors:Becker, S., Groner, B., Muller, C.W.
Deposit date:1998-06-03
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Three-dimensional structure of the Stat3beta homodimer bound to DNA.
Nature, 394, 1998
1CN4
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ERYTHROPOIETIN COMPLEXED WITH EXTRACELLULAR DOMAINS OF ERYTHROPOIETIN RECEPTOR
Descriptor:PROTEIN (ERYTHROPOIETIN RECEPTOR), PROTEIN (ERYTHROPOIETIN)
Authors:Stroud, R.M., Reid, S.W.
Deposit date:1999-05-25
Release date:1999-08-11
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Efficiency of signalling through cytokine receptors depends critically on receptor orientation.
Nature, 395, 1998
1EBA
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COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN INACTIVE PEPTIDE [EMP33] CONTAINS 3,5-DIBROMOTYROSINE IN POSITION 4 (DENOTED DBY)
Descriptor:PROTEIN (ERYTHROPOIETIN RECEPTOR), PROTEIN (EPO MIMETICS PEPTIDE 33)
Authors:Livnah, O., Stura, E.A., Wilson, I.A.
Deposit date:1998-10-02
Release date:1998-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation.
Nat.Struct.Biol., 5, 1998
1EBP
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COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN AGONIST PEPTIDE [EMP1]
Descriptor:EPO RECEPTOR, EPO MIMETICS PEPTIDE 1
Authors:Livnah, O., Stura, E.A., Wilson, I.A.
Deposit date:1996-05-07
Release date:1997-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A.
Science, 273, 1996
1EER
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CRYSTAL STRUCTURE OF HUMAN ERYTHROPOIETIN COMPLEXED TO ITS RECEPTOR AT 1.9 ANGSTROMS
Descriptor:ERYTHROPOIETIN, ERYTHROPOIETIN RECEPTOR
Authors:Syed, R.S., Li, C.
Deposit date:1998-07-24
Release date:1999-10-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Efficiency of signalling through cytokine receptors depends critically on receptor orientation.
Nature, 395, 1998
1ERN
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NATIVE STRUCTURE OF THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP]
Descriptor:PROTEIN (ERYTHROPOIETIN RECEPTOR)
Authors:Livnah, O., Stura, E.A., Wilson, I.A.
Deposit date:1999-01-11
Release date:2000-01-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation.
Science, 283, 1999
2MV6
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SOLUTION STRUCTURE OF THE TRANSMEMBRANE DOMAIN AND THE JUXTA-MEMBRANE DOMAIN OF THE ERYTHROPOIETIN RECEPTOR IN MICELLES
Descriptor:Erythropoietin receptor
Authors:Li, Q., Wong, Y., Huang, Q., Kang, C.
Deposit date:2014-09-23
Release date:2014-12-10
Method:SOLUTION NMR
Cite:Structural insight into the transmembrane domain and the juxtamembrane region of the erythropoietin receptor in micelles.
Biophys.J., 107, 2014
4Y5V
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DIABODY 305 COMPLEX WITH EPOR
Descriptor:diabody 305 VH domain, Diabody 305 VL domain, Erythropoietin receptor, ...
Authors:Moraga, I., Guo, F., Ozkan, E., Jude, K.M., Garcia, K.C.
Deposit date:2015-02-12
Release date:2015-04-29
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands.
Cell, 160, 2015
4Y5X
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DIABODY 305 COMPLEX WITH EPOR
Descriptor:diabody 310 VL domain, diabody 310 VH domain, Erythropoietin receptor, ...
Authors:Moraga, I., Guo, F., Ozkan, E., Jude, K.M., Garcia, K.C.
Deposit date:2015-02-12
Release date:2015-03-18
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands.
Cell, 160, 2015
4Y5Y
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DIABODY 330 COMPLEX WITH EPOR
Descriptor:diabody 330 VH domain, diabody 330 VL domain, Erythropoietin receptor, ...
Authors:Moraga, I., Guo, F., Ozkan, E., Jude, K.M., Garcia, K.C.
Deposit date:2015-02-12
Release date:2015-03-18
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands.
Cell, 160, 2015
168889
PDB entries from 2020-09-16