6QHD

Lysine acetylated and tyrosine phosphorylated STAT3 in a complex with DNA

Summary for 6QHD

• Entry DOI: 10.2210/pdb6qhd/pdb
• Descriptor: Signal transducer and activator of transcription 3, DNA (5'-D(*AP*AP*GP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*TP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*CP*T)-3'), ... (4 entities in total)
• Functional Keywords: lysine acetylation, dna binding, post translational modification, non canonical amino acid, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 147542.48

Authors

Arbely, E.,Belo, Y.,Shahar, A.,Zarivach, R. (deposition date: 2019-01-16, release date: 2019-06-19, Last modification date: 2024-01-24)

• Primary citation: Belo, Y.,Mielko, Z.,Nudelman, H.,Afek, A.,Ben-David, O.,Shahar, A.,Zarivach, R.,Gordan, R.,Arbely, E.; Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine.; Biochim Biophys Acta Gen Subj, 1863:1343-1350, 2019; PubMed: 31170499; DOI: 10.1016/j.bbagen.2019.05.019

Experimental method

X-RAY DIFFRACTION (2.85 Å)