6GFA

Structure of Nucleotide binding domain of HSP110, ATP and Mg2+ complexed

Summary for 6GFA

Entry DOI	10.2210/pdb6gfa/pdb
Descriptor	Heat shock protein 105 kDa, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywords	hsp110, hsp110de9, nucleotide-binding domain, hsph1, hsp105, chaperone
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	42750.42
Authors	Gonzalez, D.,Gotthard, G.,Gozzi, G.J.,Seigneuric, R.,Neiers, F.,Briand, L.,Garrido, C. (deposition date: 2018-04-29, release date: 2019-05-08, Last modification date: 2024-01-17)
Primary citation	Gozzi, G.J.,Gonzalez, D.,Boudesco, C.,Dias, A.M.M.,Gotthard, G.,Uyanik, B.,Dondaine, L.,Marcion, G.,Hermetet, F.,Denis, C.,Hardy, L.,Suzanne, P.,Douhard, R.,Jego, G.,Dubrez, L.,Demidov, O.N.,Neiers, F.,Briand, L.,Sopkova-de Oliveira Santos, J.,Voisin-Chiret, A.S.,Garrido, C. Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy. Cell Death Differ., 27:117-129, 2020 Cited by PubMed: 31068676 DOI: 10.1038/s41418-019-0343-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation