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2IZV

CRYSTAL STRUCTURE OF SOCS-4 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 2.55A RESOLUTION

Summary for 2IZV
Entry DOI10.2210/pdb2izv/pdb
Related1LM8 1LQB 1VCB 2C9W
DescriptorSUPPRESSOR OF CYTOKINE SIGNALING 4, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, ... (7 entities in total)
Functional Keywordssignal transduction inhibitor, growth regulation, signal transduction, sh2 domain, transcription, nuclear protein, ubl conjugation pathway, transcription regulation
Biological sourceHOMO SAPIENS (HUMAN)
More
Total number of polymer chains3
Total formula weight45979.62
Authors
Debreczeni, J.E.,Bullock, A.,Papagrigoriou, E.,Turnbull, A.,Pike, A.C.W.,Gorrec, F.,von Delft, F.,Sundstrom, M.,Arrowsmith, C.,Weigelt, J.,Edwards, A.,Knapp, S. (deposition date: 2006-07-26, release date: 2006-08-02, Last modification date: 2023-12-13)
Primary citationBullock, A.N.,Rodriguez, M.C.,Debreczeni, J.E.,Songyang, Z.,Knapp, S.
Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.
Structure, 15:1493-1504, 2007
Cited by
PubMed: 17997974
DOI: 10.1016/j.str.2007.09.016
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.55 Å)
Structure validation

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