2IZV

CRYSTAL STRUCTURE OF SOCS-4 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 2.55A RESOLUTION

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	SUPPRESSOR OF CYTOKINE SIGNALING 4	polymer	187	21736.7	1	UniProt (Q8WXH5) Pfam (PF00017) Pfam (PF07525) In PDB	HOMO SAPIENS (HUMAN)	SOCS-4 ELONGIN B, C COMPLEX, SOCS-4, SOCS-7, SUPPRESSOR OF CYTOKINE SIGNALING 7
2	B	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2	polymer	118	13147.8	1	UniProt (Q15370) Pfam (PF00240) In PDB	HOMO SAPIENS (HUMAN)	RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT B, SIII P18, ELONGIN B, ELOB, ELONGIN 18 KDA SUBUNIT
3	C	TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1	polymer	97	10974.6	1	UniProt (Q15369) Pfam (PF03931) In PDB	HOMO SAPIENS (HUMAN)	RNA POLYMERASE II TRANSCRIPTION FACTOR SIII SUBUNIT C, SIII P15, ELONGIN-C, ELOC, ELONGIN 15 KDA SUBUNIT
4	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
7		water	water		18.0	113	Chemie (HOH)

Sequence modifications

A: 251 - 273 (PDB: 2IZV)
A: 274 - 437 (UniProt: Q8WXH5)
C: 16 - 16 (PDB: 2IZV)
C: 17 - 112 (UniProt: Q15369)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	45859.1
Non-Polymers*	Number of molecules	3
	Total formula weight	120.5
All*	Total formula weight	45979.6

*Water molecules are not included.