2IZV
CRYSTAL STRUCTURE OF SOCS-4 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 2.55A RESOLUTION
Summary for 2IZV
Entry DOI | 10.2210/pdb2izv/pdb |
Related | 1LM8 1LQB 1VCB 2C9W |
Descriptor | SUPPRESSOR OF CYTOKINE SIGNALING 4, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 2, TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 1, ... (7 entities in total) |
Functional Keywords | signal transduction inhibitor, growth regulation, signal transduction, sh2 domain, transcription, nuclear protein, ubl conjugation pathway, transcription regulation |
Biological source | HOMO SAPIENS (HUMAN) More |
Total number of polymer chains | 3 |
Total formula weight | 45979.62 |
Authors | Debreczeni, J.E.,Bullock, A.,Papagrigoriou, E.,Turnbull, A.,Pike, A.C.W.,Gorrec, F.,von Delft, F.,Sundstrom, M.,Arrowsmith, C.,Weigelt, J.,Edwards, A.,Knapp, S. (deposition date: 2006-07-26, release date: 2006-08-02, Last modification date: 2023-12-13) |
Primary citation | Bullock, A.N.,Rodriguez, M.C.,Debreczeni, J.E.,Songyang, Z.,Knapp, S. Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation. Structure, 15:1493-1504, 2007 Cited by PubMed: 17997974DOI: 10.1016/j.str.2007.09.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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