1LQB

Crystal structure of a hydroxylated HIF-1 alpha peptide bound to the pVHL/elongin-C/elongin-B complex

Summary for 1LQB

DescriptorElongin B, Elongin C, von hippel-lindau disease tumor supressor, ... (6 entities in total)
Functional Keywordsprotein-peptide complex, tumor suppressor, cancer, proteosomal degradation, ubiquitin, prolyl hydroxylation, gene regulation
Biological sourceHomo sapiens (human)
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Cellular locationNucleus (Probable) Q15370 Q15369
Isoform 1: Cytoplasm. Isoform 3: Cytoplasm P40337
Cytoplasm Q16665
Total number of polymer chains4
Total molecular weight46768.89
Authors
Hon, W.C.,Wilson, M.I.,Harlos, K.,Claridge, T.D.,Schofield, C.J.,Pugh, C.W.,Maxwell, P.H.,Ratcliffe, P.J.,Stuart, D.I.,Jones, E.Y. (deposition date: 2002-05-09, release date: 2002-07-03, Last modification date: 2011-07-13)
Primary citation
Hon, W.C.,Wilson, M.I.,Harlos, K.,Claridge, T.D.,Schofield, C.J.,Pugh, C.W.,Maxwell, P.H.,Ratcliffe, P.J.,Stuart, D.I.,Jones, E.Y.
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Nature, 417:975-978, 2002
PubMed: 12050673 (PDB entries with the same primary citation)
DOI: 10.1038/nature00767
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26615 0.6% 2.4% 2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02