2IZV
CRYSTAL STRUCTURE OF SOCS-4 IN COMPLEX WITH ELONGIN-B AND ELONGIN-C AT 2.55A RESOLUTION
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0035556 | biological_process | intracellular signal transduction |
B | 0001222 | molecular_function | transcription corepressor binding |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006367 | biological_process | transcription initiation at RNA polymerase II promoter |
B | 0006368 | biological_process | transcription elongation by RNA polymerase II |
B | 0016567 | biological_process | protein ubiquitination |
B | 0030891 | cellular_component | VCB complex |
B | 0031462 | cellular_component | Cul2-RING ubiquitin ligase complex |
B | 0031466 | cellular_component | Cul5-RING ubiquitin ligase complex |
B | 0031625 | molecular_function | ubiquitin protein ligase binding |
B | 0032436 | biological_process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
B | 0065003 | biological_process | protein-containing complex assembly |
B | 0070449 | cellular_component | elongin complex |
B | 0140958 | biological_process | target-directed miRNA degradation |
C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A1430 |
Chain | Residue |
A | SER313 |
A | GLN315 |
A | TYR318 |
A | EDO1431 |
A | HOH2022 |
A | HOH2023 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE EDO A1431 |
Chain | Residue |
A | LEU319 |
A | GLU421 |
A | NA1430 |
A | HOH2020 |
A | ASP312 |
A | SER313 |
A | TYR318 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylmethionine => ECO:0000269|Ref.6, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
B | MET1 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62869 |
Chain | Residue | Details |
B | THR84 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62869 |
Chain | Residue | Details |
B | SER108 | |
B | SER111 |