1LM8

Structure of a HIF-1a-pVHL-ElonginB-ElonginC Complex

Summary for 1LM8

DescriptorELONGIN B, ELONGIN C, Von Hippel-Lindau disease tumor suppressor, ... (5 entities in total)
Functional Keywordsregulation, tumor suppressor, oxygen sensing, transcription
Biological sourceHomo sapiens (human)
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Cellular locationNucleus  Q15370 Q15369
Isoform 1: Cytoplasm. Isoform 3: Cytoplasm P40337
Cytoplasm  Q16665
Total number of polymer chains4
Total molecular weight44977.09
Authors
Min, J.-H.,Yang, H.,Ivan, M.,Gertler, F.,Kaelin JR., W.G.,Pavletich, N.P. (deposition date: 2002-04-30, release date: 2002-06-12, Last modification date: 2018-01-24)
Primary citation
Min, J.H.,Yang, H.,Ivan, M.,Gertler, F.,Kaelin Jr., W.G.,Pavletich, N.P.
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
Science, 296:1886-1889, 2002
PubMed: 12004076 (PDB entries with the same primary citation)
DOI: 10.1126/science.1073440
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers15 1.1% 4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171313
PDB entries from 2020-11-18