1VCB

THE VHL-ELONGINC-ELONGINB STRUCTURE

Summary for 1VCB

Entry DOI	10.2210/pdb1vcb/pdb
Descriptor	PROTEIN (ELONGIN B), PROTEIN (ELONGIN C), PROTEIN (VHL), ... (4 entities in total)
Functional Keywords	tumor suppressor, cancer, ubiquitin, beta sandwich, transcription, transcriptional elongation
Biological source	Homo sapiens (human) More
Cellular location	Nucleus (Probable): Q15370 Q15369 Isoform 1: Cytoplasm. Isoform 3: Cytoplasm: P40337
Total number of polymer chains	12
Total formula weight	176764.31
Authors	Stebbins, C.E.,Kaelin, W.G.,Pavletich, N.P. (deposition date: 1999-03-13, release date: 1999-04-21, Last modification date: 2023-12-27)
Primary citation	Stebbins, C.E.,Kaelin Jr., W.G.,Pavletich, N.P. Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. Science, 284:455-461, 1999 Cited by PubMed: 10205047 DOI: 10.1126/science.284.5413.455 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation