6DLG

Crystal structure of a SHIP1 surface entropy reduction mutant

Summary for 6DLG

Entry DOI	10.2210/pdb6dlg/pdb
Descriptor	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, ISOPROPYL ALCOHOL (3 entities in total)
Functional Keywords	hydrolase, pi3k, pip3, pi-3, 4-p2, apoptosis, immunity
Biological source	Mus musculus (Mouse)
Total number of polymer chains	1
Total formula weight	52567.38
Authors	Gardill, B.R.,Cheung, S.T.,Mui, A.L.,Van Petegem, F. (deposition date: 2018-06-01, release date: 2019-06-05, Last modification date: 2024-03-13)
Primary citation	Chamberlain, T.C.,Cheung, S.T.,Yoon, J.S.J.,Ming-Lum, A.,Gardill, B.R.,Shakibakho, S.,Dzananovic, E.,Ban, F.,Samiea, A.,Jawanda, K.,Priatel, J.,Krystal, G.,Ong, C.J.,Cherkasov, A.,Andersen, R.J.,McKenna, S.A.,Van Petegem, F.,Mui, A.L. Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes Biorxiv, 2020 Cited by DOI: 10.1101/2020.05.29.123943 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.499 Å)

Structure validation