6DJP
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INTEGRIN ALPHA-V BETA-8 IN COMPLEX WITH THE FABS 8B8 AND 68
Descriptor:Integrin alpha-v, Integrin beta-8, 8B8 heavy chain Fab, ...
Authors:Cormier, A., Campbell, M.G., Nishimura, S.L., Cheng, Y.
Deposit date:2018-05-25
Release date:2018-07-25
Last modified:2018-08-15
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Cryo-EM structure of the alpha v beta 8 integrin reveals a mechanism for stabilizing integrin extension.
Nat. Struct. Mol. Biol., 25, 2018
6AVQ
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THE THERAPEUTIC ANTIBODY LM609 SELECTIVELY INHIBITS LIGAND BINDING TO HUMAN ALPHA-V BETA-3 INTEGRIN VIA STERIC HINDRANCE
Descriptor:Integrin alpha-V, Integrin beta-3, LM609 Fab heavy chain, ...
Authors:Borst, A.J., James, Z.N., Zagotta, W.N., Ginsberg, M., Rey, F.A., DiMaio, F., Backovic, M., Veesler, D.
Deposit date:2017-09-04
Release date:2017-11-01
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (35 Å)
Cite:The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017
6AVR
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HUMAN ALPHA-V BETA-3 INTEGRIN (INTERMEDIATE CONFORMATION) IN COMPLEX WITH THE THERAPEUTIC ANTIBODY LM609
Descriptor:Integrin alpha-V, Integrin beta-3, Fab LM609 heavy chain, ...
Authors:Borst, A.J., James, Z.N., Zagotta, W.N., Ginsberg, M., Rey, F.A., DiMaio, F., Backovic, M., Veesler, D.
Deposit date:2017-09-04
Release date:2017-11-01
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (35 Å)
Cite:The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017
6AVU
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HUMAN ALPHA-V BETA-3 INTEGRIN (OPEN CONFORMATION) IN COMPLEX WITH THE THERAPEUTIC ANTIBODY LM609
Descriptor:Integrin alpha-V, Integrin beta-3, Fab LM609 heavy chain, ...
Authors:Borst, A.J., James, Z.N., Zagotta, W.N., Ginsberg, M., Rey, F.A., DiMaio, F., Backovic, M., Veesler, D.
Deposit date:2017-09-04
Release date:2017-11-01
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (35 Å)
Cite:The Therapeutic Antibody LM609 Selectively Inhibits Ligand Binding to Human alpha V beta 3 Integrin via Steric Hindrance.
Structure, 25, 2017
5ES4
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RE-REFINEMENT OF INTEGRIN ALPHAXBETA2 ECTODOMAIN IN THE CLOSED/BENT CONFORMATION
Descriptor:Integrin alpha-X, Integrin beta-2, CALCIUM ION, ...
Authors:Sen, M., Springer, T.A.
Deposit date:2015-11-16
Release date:2016-03-02
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Leukocyte integrin alpha L beta 2 headpiece structures: The alpha I domain, the pocket for the internal ligand, and concerted movements of its loops.
Proc.Natl.Acad.Sci.USA, 113, 2016
4O02
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ALPHAVBETA3 INTEGRIN IN COMPLEX WITH MONOCLONAL ANTIBODY FAB FRAGMENT.
Descriptor:Integrin alpha-V, Integrin beta-3, 17E6 light chain, ...
Authors:Mahalingam, B., van Agthoven, J., Xiong, J., Arnaout, M.A.
Deposit date:2013-12-13
Release date:2014-04-02
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (3.605 Å)
Cite:Atomic basis for the species-specific inhibition of alpha V integrins by monoclonal antibody 17E6 is revealed by the crystal structure of alpha V beta 3 ectodomain-17E6 Fab complex.
J.Biol.Chem., 289, 2014
4NEH
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AN INTERNAL LIGAND-BOUND, METASTABLE STATE OF A LEUKOCYTE INTEGRIN, AXB2
Descriptor:Integrin alpha-X, Integrin beta-2, CALCIUM ION, ...
Authors:Sen, M., Yuki, K., Springer, T.A.
Deposit date:2013-10-29
Release date:2014-01-15
Method:X-RAY DIFFRACTION (2.7505 Å)
Cite:An internal ligand-bound, metastable state of a leukocyte integrin, alpha X beta 2.
J.Cell Biol., 203, 2013
4NEN
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AN INTERNAL LIGAND-BOUND, METASTABLE STATE OF A LEUKOCYTE INTEGRIN, AXB2
Descriptor:Integrin alpha-X, Integrin beta-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Sen, M., Yuki, K., Springer, T.A.
Deposit date:2013-10-29
Release date:2014-01-15
Method:X-RAY DIFFRACTION (2.9012 Å)
Cite:An internal ligand-bound, metastable state of a leukocyte integrin, alpha X beta 2.
J.Cell Biol., 203, 2013
4CAK
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THREE-DIMENSIONAL RECONSTRUCTION OF INTACT HUMAN INTEGRIN ALPHAIIBBETA3 IN A PHOSPHOLIPID BILAYER NANODISC
Descriptor:INTEGRIN ALPHA-IIB, INTEGRIN BETA-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Choi, W.S., Rice, W.J., Stokes, D.L., Coller, B.S.
Deposit date:2013-10-08
Release date:2013-10-30
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (20.5 Å)
Cite:Three-Dimensional Reconstruction of Intact Human Integrin Alphaiibbeta3; New Implications for Activation-Dependent Ligand Binding.
Blood, 122, 2013
4MMX
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INTEGRIN ALPHAVBETA3 ECTODOMAIN BOUND TO THE TENTH DOMAIN OF FIBRONECTIN
Descriptor:Integrin alpha-V, Integrin beta-3, Fibronectin, ...
Authors:van Agthoven, J., Xiong, J., Arnaout, M.A.
Deposit date:2013-09-09
Release date:2014-03-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.32 Å)
Cite:Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin.
Nat.Struct.Mol.Biol., 21, 2014
4MMY
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INTEGRIN ALPHAVBETA3 ECTODOMAIN BOUND TO THE TENTH DOMAIN OF FIBRONECTIN WITH THE IAKGDWND MOTIF
Descriptor:Integrin alpha-V, Integrin beta-3, Fibronectin, ...
Authors:van Agthoven, J., Xiong, J., Arnaout, M.A.
Deposit date:2013-09-09
Release date:2014-03-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.183 Å)
Cite:Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin.
Nat.Struct.Mol.Biol., 21, 2014
4MMZ
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INTEGRIN ALPHAVBETA3 ECTODOMAIN BOUND TO AN ANTAGONISTIC TENTH DOMAIN OF FIBRONECTIN
Descriptor:Integrin alpha-V, Integrin beta-3, Fibronectin, ...
Authors:van Agthoven, J., Xiong, J., Arnaout, M.A.
Deposit date:2013-09-09
Release date:2014-03-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.102 Å)
Cite:Structural basis for pure antagonism of integrin alpha V beta 3 by a high-affinity form of fibronectin.
Nat.Struct.Mol.Biol., 21, 2014
4G1E
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CRYSTAL STRUCTURE OF INTEGRIN ALPHA V BETA 3 WITH COIL-COILED TAG.
Descriptor:Integrin alpha-V, Integrin beta-3, CALCIUM ION, ...
Authors:Dong, X., Mi, L., Zhu, J., Wang, W., Luo, B., Springer, T.A.
Deposit date:2012-07-10
Release date:2012-12-05
Method:X-RAY DIFFRACTION (3 Å)
Cite:AlphaV Beta3 Integrin Crystal Structures and their Functional Implications
Biochemistry, 51, 2012
4G1M
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RE-REFINEMENT OF ALPHA V BETA 3 STRUCTURE
Descriptor:Integrin alpha-V, Integrin beta-3, CALCIUM ION, ...
Authors:Springer, T.A., Mi, L., Zhu, J.
Deposit date:2012-07-10
Release date:2012-12-05
Last modified:2012-12-19
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Alpha V Beta 3 Integrin Crystal Structures and their Functional Implications
Biochemistry, 51, 2012
3K71
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STRUCTURE OF INTEGRIN ALPHAX BETA2 ECTODOMAIN
Descriptor:Integrin alpha-X, Integrin beta-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xie, C., Zhu, J., Chen, X., Mi, L., Nishida, N., Springer, T.A.
Deposit date:2009-10-11
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.95 Å)
Cite:Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
3K72
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STRUCTURE OF INTEGRIN ALPHAX BETA2
Descriptor:Integrin alpha-X, Integrin beta-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xie, C., Zhu, J., Chen, X., Mi, L., Nishida, N., Springer, T.A.
Deposit date:2009-10-11
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
3K6S
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STRUCTURE OF INTEGRIN ALPHAXBETA2 ECTODOMAIN
Descriptor:Integrin alpha-X, Integrin beta-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xie, C., Zhu, J., Chen, X., Mi, L., Nishida, N., Springer, T.A.
Deposit date:2009-10-09
Release date:2010-01-12
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of an integrin with an alphaI domain, complement receptor type 4.
Embo J., 29, 2010
3IJE
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CRYSTAL STRUCTURE OF THE COMPLETE INTEGRIN ALHAVBETA3 ECTODOMAIN PLUS AN ALPHA/BETA TRANSMEMBRANE FRAGMENT
Descriptor:Integrin alpha-V, Integrin beta-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xiong, J.-P., Mahalingham, B., Rui, X., Hyman, B.T., Goodman, S.L., Arnaout, M.A.
Deposit date:2009-08-04
Release date:2009-09-29
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.
J.Cell Biol., 186, 2009
3FCS
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STRUCTURE OF COMPLETE ECTODOMAIN OF INTEGRIN AIIBB3
Descriptor:Integrin, alpha 2b, Integrin beta-3, ...
Authors:Zhu, J., Luo, B.-H., Xiao, T., Zhang, C., Nishida, N., Springer, T.A.
Deposit date:2008-11-22
Release date:2009-01-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces.
Mol.Cell, 32, 2008
1U8C
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A NOVEL ADAPTATION OF THE INTEGRIN PSI DOMAIN REVEALED FROM ITS CRYSTAL STRUCTURE
Descriptor:Integrin alpha-V, Integrin beta-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xiong, J.P., Stehle, T., Goodman, S.L., Arnaout, M.A.
Deposit date:2004-08-05
Release date:2004-12-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A novel adaptation of the integrin PSI domain revealed from its crystal structure.
J.Biol.Chem., 279, 2004
1M1X
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHA VBETA3 BOUND TO MN2+
Descriptor:Integrin alpha-V, Integrin beta-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Xiong, J.-P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S.L., Arnaout, M.A.
Deposit date:2002-06-20
Release date:2002-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.
Science, 296, 2002
1L5G
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN AVB3 IN COMPLEX WITH AN ARG-GLY-ASP LIGAND
Descriptor:INTEGRIN ALPHA V, INTEGRIN BETA-3, CYCLIC ARG-GLY-ASP PEPTIDE, ...
Authors:Xiong, J.-P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S.L., Arnaout, M.A.
Deposit date:2002-03-06
Release date:2002-04-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.
Science, 296, 2002
1JV2
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CRYSTAL STRUCTURE OF THE EXTRACELLULAR SEGMENT OF INTEGRIN ALPHAVBETA3
Descriptor:INTEGRIN, ALPHA V, PLATELET MEMBRANE GLYCOPROTEIN IIIA BETA SUBUNIT, ...
Authors:Xiong, J.P., Stehle, T., Diefenbach, B., Zhang, R., Dunker, R., Scott, D., Joachimiak, A., Goodman, S.L., Arnaout, M.A.
Deposit date:2001-08-28
Release date:2001-10-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of the extracellular segment of integrin alpha Vbeta3.
Science, 294, 2001
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