6MSL

Integrin AlphaVBeta3 ectodomain bound to EETI-II 2.5D

Summary for 6MSL

Entry DOI	10.2210/pdb6msl/pdb
Related	3IJE 4G1E 4G1M 4MMX 4MMY 4MMZ
Descriptor	Integrin alpha-V, Integrin beta-3, Cystine Knot Protein 2.5D, ... (10 entities in total)
Functional Keywords	hybrid domain, psi, egf repeats, beta tail, calf, thigh, beta propeller, rgd motif, fibronectin, vitronectin, cell adhesion
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	193657.95
Authors	van Agthoven, J.F.,Arnaout, M.A. (deposition date: 2018-10-16, release date: 2019-10-23, Last modification date: 2023-10-11)
Primary citation	Van Agthoven, J.F.,Shams, H.,Cochran, F.V.,Alonso, J.L.,Kintzing, J.R.,Garakani, K.,Adair, B.D.,Xiong, J.P.,Mofrad, M.R.K.,Cochran, J.R.,Arnaout, M.A. Structural Basis of the Differential Binding of Engineered Knottins to Integrins alpha V beta 3 and alpha 5 beta 1. Structure, 27:1443-1451.e6, 2019 Cited by PubMed: 31353240 DOI: 10.1016/j.str.2019.06.011 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.104 Å)

Structure validation